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Patent # Description
US-1,007,7311 Human antibodies to GFR alpha3 and methods of reducing pain associated with GFR alpha3-related diseases
The present invention provides antibodies that bind to human GFR.alpha.3 and methods of using same. According to certain embodiments of the invention, the...
US-1,007,7309 Compositions and methods for targeting of the surfactant protein A receptor
Provided are compositions and methods for use in prophylaxis, therapy and diagnosis of conditions which involve surfactant protein receptors (SPR) including the...
US-1,007,7308 PD-L1 specific monoclonal antibodies for disease treatment and diagnosis
The present invention relates to compositions and methods for immunotherapy of a subject afflicted with diseases such as cancer, an infectious disease, or a...
US-1,007,7306 Antibodies against TIM3 and uses thereof
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also...
US-1,007,7305 Antibodies against PD-1 and uses thereof
The present invention provides antibodies and antigen-binding fragments that specifically bind PD-1 (Programmed Death 1), thereby modulating immune responses in...
US-1,007,7304 Antibodies against frizzled receptor
This invention provides monoclonal antibodies that recognize one or more Frizzled receptors. The invention further provides methods of using such monoclonal...
US-1,007,7303 Anti-neurotensin antibodies and uses thereof
The present invention relates to a neutralizing antibody which is capable of binding to neurotensin with high affinity. The antibody of the present invention...
US-1,007,7302 Method of inhibiting human IL-1 beta by administering an antibody to human IL-1 beta
The present invention relates to anti-IL-1 beta binding members and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly...
US-1,007,7301 IL-21 binding proteins
The present disclosure provides proteins comprising antigen binding sites of antibodies that bind to interleukin-21 (IL-21) and uses thereof, e.g., in therapy.
US-1,007,7300 Activatable binding polypeptides and methods of identification and use thereof
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided....
US-1,007,7299 Method for refining protein including self-cutting cassette and use thereof
The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by LPXTG, a...
US-1,007,7298 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an...
US-1,007,7297 Fc fusion high affinity IgE receptor .alpha.-chain
Provided is an Fc fusion high affinity IgE receptor .alpha.-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity...
US-1,007,7296 Methods and compositions for the treatment and prevention of cancer
The instant invention provides compositions for the treatment of cancer. Specifically, the invention provides polypeptides and nucleic acid molecules comprising...
US-1,007,7295 Glycoproteins having lipid mobilizing properties and therapeutic uses thereof
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as cachexia, hypoglycemia, obesity,...
US-1,007,7294 Peptide inhibitors of TEAD/YAP-TAZ interaction
The invention relates to an isolated peptide inhibitor of the interaction between the TEAD and YAP or TAZ proteins and a derived chimeric peptide linked to a...
US-1,007,7293 Antimicrobial peptide analogues derived from abalone (Haliotis discus) and antimicrobial pharmaceutical...
The present disclosure relates to an antimicrobial peptide analog derived from abalone and an antimicrobial pharmaceutical composition containing the same. The...
US-1,007,7292 Formaldehyde-free proteinaceous binder compositions
Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second...
US-1,007,7291 Methods and compositions for dual glycan binding AAV vectors
The present invention provides methods and compositions comprising an adeno-associated virus (AAV) capsid protein, comprising one or more amino acids...
US-1,007,7290 Stabilized antiviral fusion helices
Internally cross-linked peptides useful for interfering with Respiratory Syncytial Virus (RSV) infection is based on RSV-F protein. These peptides are capable...
US-1,007,7289 Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using...
US-1,007,7288 Hydroxystatin derivatives for the treatment of arthrosis
The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula (I) for use in...
US-1,007,7287 Tubulysin analogs and methods of making and use
Tubulysin analogs of the formula (I) ##STR00001## where R.sup.1, R.sup.2 R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and Y are as defined herein, are...
US-1,007,7286 Method for removal of triglycerides in lipoproteins other than low-density lipoproteins
Disclosed is a method for selectively eliminating triglycerides in lipoproteins other than low density lipoprotein, which method allows one to provide a method...
US-1,007,7285 Enhanced functionality and delivery of a protein from a porous substrate
Compositions, methods, articles of manufacture, and kits are provided for storage and delivery of proteins.
US-1,007,7284 UBA5 inhibitors
The present disclosure relates to compounds of the Formula (I), which are UBA5 inhibitors.
US-1,007,7283 Process for fractionating lignocellulosics
A method for the isolation of lignin from a lignocellulosic biomass, comprising providing a lignocellulosic biomass; extracting sugar free lignin from the...
US-1,007,7282 Raw material for chemical deposition composed of organoplatinum compound, and chemical deposition method using...
The present invention relates to a raw material for chemical deposition shown in a formulae below and including an organoplatinum compound in which diimine...
US-1,007,7281 Crystalline ligand
A ligand crystal structure of 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bi- s(oxy)]bisdibenzo[d,f][1,3,2]-dioxaphosphepin. Formule...
US-1,007,7280 Mixed ligand gold(I) complexes as anti-cancer agents
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
US-1,007,7279 Vinylsilanes for use in functionalized elastomeric polymers
The present invention relates to novel vinylsilane compounds which are useful as modifying monomers in the polymerization of conjugated diene monomers,...
US-1,007,7278 Synthetic methods for diboron reagents and related compounds
The disclosure is directed to diboron compounds, related methods of making, and related intermediate boron and diboron compounds used to make the same. The...
US-1,007,7277 Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
This application relates to derivatives of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and...
US-1,007,7276 N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
The present invention relates to compounds of formula I: ##STR00001## in which p, q, Y.sub.1, Y.sub.2, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
US-1,007,7275 Process for production of a spiroglycol
Disclosed is a process for production of a spiroglycol by subjecting pentaerythritol to reaction in water with hydroxypivaldehyde in presence of a catalytically...
US-1,007,7274 UV-curing-compatible photochromic fused naphthopyrans
The present invention relates to UV-curing-compatible photochromic single- or double-fused naphthopyrans of the general formulae (I) or (II) and the use thereof...
US-1,007,7273 SHMT inhibitors
The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have...
US-1,007,7272 Heteroaromatic compounds and their use as dopamine D1 ligands
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
US-1,007,7271 Methods and compositions for inhibiting the interaction of menin with MLL proteins
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The...
US-1,007,7270 HIV inhibiting bicyclic pyrimidine derivatives
HIV replication inhibitors of formula ##STR00001## wherein -a.sup.1=a.sup.2-a.sup.3=a.sup.4- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--,...
US-1,007,7269 Imidazopyridazine compounds
The present invention is directed to compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the substituents R.sup.1,...
US-1,007,7268 FXR agonists and methods for making and using
Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are...
US-1,007,7267 Organic compounds
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or...
US-1,007,7266 Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
The present invention provides compounds of formula I: ##STR00001## which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for...
US-1,007,7265 Substituted oxopyridine derivatives
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments...
US-1,007,7264 Derivatives and methods of treating hepatitis B infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
US-1,007,7263 Process for the preparation of Apixaban
The present invention relates to an improved process for the preparation of Apixaban and its intermediates.
US-1,007,7262 Thienothiadiazole compounds and related semiconductor devices
The present invention relates to new semiconducting compounds having at least one optionally substituted thienothiadiazole moiety. The compounds disclosed...
US-1,007,7261 Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of...
US-1,007,7260 Read-through compound prodrugs suppressing premature nonsense mutations
Premature termination codon readthrough prodrug compounds, compositions thereof, and methods of making and using the same are provided. In certain embodiments,...
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