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Patent # Description
US-1,008,5999 Beta-lactamase inhibitors and uses thereof
.beta.-Lactamase inhibiting compounds, therapeutic methods of using the .beta.-lactamase inhibiting compounds, particularly in combination with .beta.-lactam...
US-1,008,5998 Salts of potassium ATP channel openers and uses thereof
Provided are immediate or prolonged administration of certain salts of K.sub.ATP channel openers such as diazoxide to a subject to achieve novel ...
US-1,008,5997 Method of treating microbial infections
The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
US-1,008,5996 Pharmaceutical combinations
A pharmaceutical combination comprising: (a) a phosphatidylinositol-3-kinase inhibitor selected from ...
US-1,008,5995 Topical compositions and methods of treatment of anorectal disorders
A topical anorectal composition includes trimethylsiloxysilicate; at least one surfactant selected from the group consisting of sodium lauryl sulfate, alkyl-...
US-1,008,5994 Topical compositions and methods of treatment of topical disorders
A topical composition includes at least one film forming ingredient; at least one surfactant; at least one non-polar volatile siloxane solvent; at least 15%...
US-1,008,5993 Tablet formulation of 2-fluoro-N-methyl-4-[ 7-( quinolin-6-ylmethyl) imidazo [1,2-B] [1,2,4] triazin-2-yl]...
The present invention is related to tablets comprising of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-- 2-yl]benzamide, processes...
US-1,008,5992 Transient protection of normal cells during chemotherapy
This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and...
US-1,008,5991 Formulation inhibiting effects of low acid environment
The present invention is directed to formulations comprising PVP polymer, a dispersion of a compound of Formula I (API), and citric acid, which formulations...
US-1,008,5990 Tricyclic compounds as modulators of TNF-.alpha. synthesis and as PDE4 inhibitors
The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of...
US-1,008,5989 Compounds and compositions for the treatment of parasitic diseases
The present invention provides compounds of Formula A: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the...
US-1,008,5988 Aglaroxin C and derivatives as HCV entry inhibitors
A rocaglamide or a rocaglate derivative, particularly aglaroxin C, blocks hepatitis C virus (HCV) entry with improved potency and therapeutic index.
US-1,008,5987 MCT protein inhibitor-related prognostic and therapeutic methods
This invention provides a method of identifying one or more subgroups of cancer patients that are likely to benefit from treatment with a monocarboxylate...
US-1,008,5986 Pyrimidinone compounds and their use
The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, Y and Z are as defined in the...
US-1,008,5985 Bromodomain inhibitors
The present invention provides for compounds of formula (I) ##STR00001## wherein Y.sup.1, Y.sup.2, R.sup.1, R.sup.2, R.sup.3, A.sup.1, A.sup.2, A.sup.3, and...
US-1,008,5984 Metalloenzyme inhibitor compounds
Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
US-1,008,5983 Azabicyclo derivatives, process for preparation thereof and medical use thereof
Azabicyclo derivatives, a preparation process, and medical use thereof are provided. In particular, azabicyclo derivatives of formula (I), pharmaceutically...
US-1,008,5982 Combinations
The invention relates to a combination of a first compound selected from N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl- ...
US-1,008,5981 Protein acyl transferase inhibitors and methods of treatment
Embodiments of the present disclosure include compositions and pharmaceutical compositions that include protein acyl transferases (PAT) inhibitors, methods of...
US-1,008,5980 Aripiprazole formulations having increased injection speeds
The present invention relates to pharmaceutical compositions comprising a compound of Formula (I) that are useful for the intramuscular delivery of ...
US-1,008,5979 Combinations for the treatment of neuroblastoma
Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents....
US-1,008,5978 Procaspase combination therapy for glioblastoma
The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods...
US-1,008,5977 Procaspase 3 activation by combination therapy
The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods...
US-1,008,5976 Pharmaceutical composition for preventing or treating neurodegenerative diseases
This invention provides a method of treating a neurodegenerative disease selected from the group consisting of Parkinson's disease, dementia with Lewy bodies,...
US-1,008,5975 Selective high affinity .alpha.3.beta.4 nicotinic acetylcholine receptor antagonists
Provided herein are novel and selective high affinity .alpha.3.beta.4 nicotinic acetycholine receptor ligands and pharmaceutical compositions thereof. In other...
US-1,008,5974 Dosage and formulation
The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder of a pharmaceutically acceptable...
US-1,008,5973 Pharmaceutical composition containing a compound having a thrombopoietin receptor agonistic activity
The present inventor has found out that the following criteria enable to ensure an effect for increasing the platelet count while preventing an excessive...
US-1,008,5972 Trifluoromethyl pyrazolyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using trifluoromethyl pyrazolyl...
US-1,008,5971 Pharmaceutical solution of asenapine for sublingual or buccal use
A kit for treating psychosis by administering a pharmaceutically acceptable liquid composition of Asenapine to oral mucosa includes a formulation having...
US-1,008,5970 Use of amisulpride as an anti-emetic
Amisulpride is used in the therapy of nausea, vomiting or retches. The therapy may utilize a novel injectable formulation, in unit dosage form, comprising less...
US-1,008,5969 Sortilin binding compounds, formulations, and uses thereof
Provided herein are compounds and formulations thereof that can be capable of binding to sortilin or an analog thereof. Also provided herein are methods of...
US-1,008,5968 Multicyclic compounds and methods of use thereof
Provided herein are multicyclic compounds of formula (IVa), shown below, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, m, and n are...
US-1,008,5967 Treatment of sickle cell disease
The present invention includes embodiments for treatment and/or prevention of sickle cell disease that employ Hydroxyfasudil or Isocoronarin D alone or either...
US-1,008,5966 Compositions and methods for skin care
Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including...
US-1,008,5965 Cannabinoid alcoholic drink
Cannabinoid Alcoholic Drinks (CADs) and methods for producing CADs utilize cannabinoids dissolved in ethanol The resulting cannabinoid/ethanol solution is then...
US-1,008,5964 Ultrapure tetrahydrocannabinol-11-oic acids
This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use...
US-1,008,5963 Process and compositions for achieving mammalian energy balance
Disclosed is a method of achieving optimal mammalian energy balance using forskolin on a particular physiological and developmental stage of the mammalian...
US-1,008,5962 Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic...
Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention...
US-1,008,5961 Pharmaceutical compositions of dimethyl fumarate
The present invention relates to pharmaceutical compositions comprising dimethyl fumarate and a pharmaceutically acceptable agent which inhibits the enzyme...
US-1,008,5960 Methods and compositions for reducing ocular discomfort
The invention relates to compositions and devices which include an osmolytic agent, in particular a betaine or carnitine compound, for reducing ocular...
US-1,008,5959 Compositions and methods for treating intestinal hyperpermeability
The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions such...
US-1,008,5958 Bromfenac bioavailability
Formulations and methods that provided enhanced bromfenac penetration into ocular tissue when topically administered, compared to the currently available...
US-1,008,5957 Benzoic acid compounds for reducing uric acid
Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I. The uric acid-lowering effects of...
US-1,008,5956 Topical compositions for pain relief, manufacture and use
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of...
US-1,008,5955 Methods and compositions for treatment of demyelinating diseases
Disclosed herein are new oral pharmaceutical compositions of SAMDC inhibitors, polyamine analogs, and polyamine biosynthesis inhibitors, and their application...
US-1,008,5954 Quick dissolving diphenhydramine oral dosage form
An oral dosage form to deliver diphenhydramine through the sublingual or buccal mucosa. The oral dosage form can contain diphenhydramine, or a pharmaceutically...
US-1,008,5953 Skin cancer treatment
A compound of formula (I) R-L-CO--X (I) wherein R is a C.sub.10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups...
US-1,008,5952 Dermatitis treatment
A compound of formula (I) R-L-CO--X (I) (wherein R is a C.sub.10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups...
US-1,008,5951 Curcuminoid formulations and related methods of treatment
The invention provides novel curcuminoid formulations which have improved aqueous solubility and bioavailability when compared to known curcuminoid dosage...
US-1,008,5950 Pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients
The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the...
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