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Patent # Description
US-1,008,7259 Depleting tumor-specific tregs
The present invention provides, among other things, methods and compositions for diagnosing and/or treating cancer by targeting CCR8. In particular, the present...
US-1,008,7258 Anti-CD324 monoclonal antibodies and uses thereof
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
US-1,008,7257 SIRP alpha-antibody fusion proteins
SIRPabodies comprise an immunoglobulin variable region, which may specifically bind a tumor antigen, viral antigen, etc., fused to a sequence comprising a...
US-1,008,7256 Method of making an anti-CD40 antibody
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen...
US-1,008,7255 Anti-sortilin antibodies and methods of use thereof
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
US-1,008,7254 ASPGR antibodies and uses thereof
The present invention generally relates to antibodies specific for asialoglycoprotein receptor (ASGPR) and their use for selectively delivering effector...
US-1,008,7253 Monoclonal antibody capable of binding integrin alpha 10 beta 1
The present invention provides a monoclonal antibody or a fragment thereof binding to the extracellular I-domain of integrin alpha10beta1 and a hybridoma cell...
US-1,008,7252 Methods and compositions for treating and preventing disease associated with .alpha.v.beta.5 integrin
The present invention provides compositions and methods for treating and preventing disease associated with .alpha.v.beta.5 integrin by blocking binding to...
US-1,008,7251 Amino acid sequences that modulate the interaction between cells of the immune system
The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a...
US-1,008,7250 Fc-free antibodies comprising two fab-fragments and methods of use
The present invention relates to bispecific antibodies comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen...
US-1,008,7249 Alphabody libraries and methods for producing the same
The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody...
US-1,008,7248 Anti-TNF-.alpha./CXCL10 double-targeting antibody and use thereof
The present invention relates to a TNF-.alpha. (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG...
US-1,008,7247 Methods and compositions for delivering mRNA coded antibodies
The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof...
US-1,008,7246 Anti-PDGF-B antibodies and methods of use
Herein are reported anti-PDGF-B antibodies and their use in ophthalmology.
US-1,008,7245 Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing...
The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The...
US-1,008,7244 Humanization of rabbit antibodies using a universal antibody framework
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a...
US-1,008,7243 Compositions and methods for phagocyte delivery of anti-staphylococcal agents
The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding...
US-1,008,7242 Glycoconjugates and use thereof as vaccine against Shigella flexneri serotype 3a and X
The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for...
US-1,008,7241 Polypeptdes, cells, and methods for biofilm therapy and detection
This disclosure describes a fusion polypeptide that includes an anchor domain and a binding domain that specifically binds to a target biofilm. The anchor...
US-1,008,7240 DNA antibody constructs and method of using same
The present invention relates to a composition including a recombinant nucleic acid sequence that encodes an antibody and a method of generating a synthetic...
US-1,008,7239 Broadly neutralizing human immunodeficiency virus type 1 (HIV-1) GP120-specific monoclonal antibody
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for...
US-1,008,7238 Method of preventing myocardial reperfusion injury in reperfusion therapy by administering intravenous...
The method of preventing reperfusion injury in reperfusion therapy is a medical technique for prevention of reperfusion injury in a patient where reperfusion...
US-1,008,7237 Isoform enriched antibody preparation and method for obtaining it
Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an...
US-1,008,7236 Methods for modifying human antibodies by glycan engineering
Modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Fc regions with...
US-1,008,7235 Contaminant removal method
A method for purifying Apo A-I is provided including the steps of providing a solution comprising Apo A-I and guanidine hydrochloride and filtering the solution...
US-1,008,7234 Mimetic peptides
The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for...
US-1,008,7233 Coagulation factor VIII with reduced immunogenicity
The invention describes factor VIII molecules with reduced capacity to elicit activation of NKT cells for use in the treatment of congenital and/or acquired...
US-1,008,7232 Use of plant cells expressing a TNFalpha polypeptide inhibitor in therapy
A method of treating a TNF Alpha associated medical condition selected from the group consisting of obesity, metabolic syndrome, diabetes and a liver disease or...
US-1,008,7231 Substitution mutant receptors and their use in an ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More...
US-1,008,7230 Murine anti-NY-ESO-1 T cell receptors
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides,...
US-1,008,7229 Peptide compound
The present invention provides a novel peptide compound having an activating action on GLP-1 receptors and GIP receptors and use of the peptide compound as a...
US-1,008,7228 Chimeric leptin polypeptide and method of using the same
The disclosure provides chimeric polypeptides and nucleic acid molecules encoding chimeric polypeptides. Also provided are pharmaceutical compositions and...
US-1,008,7227 Nucleic acids encoding IL-22 Fc fusion proteins
The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of...
US-1,008,7226 Chimeric peptide that interacts with cell membrane gangliosides
The invention relates to a chimeric peptide displaying the ganglioside-binding properties of both .alpha.-synuclein and .beta.-amyloid peptide. Such peptide is...
US-1,008,7225 Formulation of MK2 inhibitor peptides
A pharmaceutical formulation comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, up to 5%...
US-1,008,7224 Gene therapy for Alzheimer's and other neurodegenerative diseases and conditions
The present invention provides compositions and methods to treat Alzheimer's disease and other neurodegenerative diseases and conditions by expressing exogenous...
US-1,008,7223 Opsin polypeptides and methods of use thereof
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
US-1,008,7222 Polynucleotides encoding angiopoietin-2 (ang-2) binding polypeptides
Complexes containing one or more modular recognition domains (MRDs) and MRDs attached to scaffolds including antibodies are described. The manufacture of these...
US-1,008,7221 Synthesis of hydantoin containing peptide products
The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a...
US-1,008,7220 Human ULIP/CRMP protein and use thereof in diagnosis and treatment of cancers and paraneoplastic neurological...
A purified polypeptide, designated ULIP6, comprising the amino acid sequence SEQ ID No. 2 or an epitopic fragment of said polypeptide, comprising the sequence...
US-1,008,7219 Human alpha-defensin 5 variant and uses thereof
A human .alpha.-defensin 5 variant is obtained by adding amino acid residues at C-terminal of .alpha.-defensin 5 and then being modified to link an aliphatic...
US-1,008,7218 Vaccine antigens that direct immunity to conserved epitopes
A method of identification and elimination of immunodominant epitopes to elicit a response to secondary epitopes, especially conserved structures, is described,...
US-1,008,7217 Adeno-associated virus with site-directed mutagenesis and site-directed modification and preparation method and...
The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses...
US-1,008,7216 Conotoxin polypeptide .kappa.-CPTx-bt101, and method for preparation thereof and application thereof
Disclosed are a conotoxin polypeptide .kappa.-CPTx-bt101, a method for preparation thereof, and an application thereof. The conotoxin polypeptide of the present...
US-1,008,7215 Stabilized SOS1 peptides
Provided herein are polypeptides containing stabilized therapeutic peptides related to KRAS guanidine exchange factor (SOS1). Also provided are compositions...
US-1,008,7214 Sterile chromatography and manufacturing processes
Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a...
US-1,008,7213 Intein mediated purification of protein
The present invention includes methods, compositions, uses, and kits for purifying a protein of interest (POI) comprising contacting a first fusion protein...
US-1,008,7212 Crystal form of Abiraterone propionate and preparation method therefor
The present invention relates to the field of pharmaceutical chemistry, and particularly to a crystal form of Abiraterone propionate and a preparation method...
US-1,008,7211 Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate...
US-1,008,7210 Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention...
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