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Patent # Description
US-1,008,7209 Antiviral compounds, a process for their preparation, and their use for treating viral infections
The present invention relates to novel pro-drugs of L-2'-deoxythreose nucleoside phosphonates, such as phosphoramidate, phosphorodiamidate and phospho-diester...
US-1,008,7208 Phosphoramidite building blocks for sugar-conjugated oligonucleotides
Novel nucleoside phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one phosphotriester linkage conjugated to a...
US-1,008,7207 Nucleotide analogs for real-time sequencing method for single molecule
This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme...
US-1,008,7206 Scalable synthesis of reduced toxicity derivative of amphotericin B
Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2'epiAmB, an efficacious...
US-1,008,7205 Metal organic frameworks comprising a plurality of SBUS with different metal ions and/or a plurality of organic...
The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs comprising different metals or metal ions and/or a plurality of...
US-1,008,7204 Methods and compositions for substituted alpha-aminophosphonate analogues
Provided herein are .alpha.-aminophosphonates and methods for making same. Also provided are N-heterocyclic phosphines (NHPs) useful in metal-free...
US-1,008,7203 Compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,008,7202 Chiral aziridine phosphoramidate compounds
The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel...
US-1,008,7201 Hydrolysis catalyst and process
A process of hydrolyzing a monodentate, bidentate or tridentate phosphorus-based phosphite ester ligand or ligand blend for a transition metal catalyst...
US-1,008,7200 Silylated imine and carbamate polymeric benzoate compounds, uses, and compositions thereof
The present invention relates to organosilicon polymers containing benzoic acid esters in form of particles, process for their preparation, cosmetic or...
US-1,008,7199 Super-resolution imaging compositions and methods using same
The invention provides compositions that may be used for imaging intracellular structures. The invention further provides methods of imaging intracellular...
US-1,008,7198 Reaction accelerator for a copolymerisation, electrical-insulation tape, electrical-insulation body, and...
A compound having the structural formula R.sup.1CO.sub.2.sup.- R.sup.2CO.sub.2.sup.- Zn.sup.2+ used as a reaction accelerator for the copolymerization of a...
US-1,008,7197 Selective extraction of anions from solution
A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper...
US-1,008,7196 Polymorphs
The invention relates to a polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-- ...
US-1,008,7195 Certain protein kinase inhibitors
Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof. ##STR00001##
US-1,008,7194 Podophyllotoxin derivatives and their use
Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
US-1,008,7193 Crystalline forms of dolutegravir sodium
The present disclosure relates to novel crystalline dolutegravir sodium Form-M2, Form-M3, Form-M4 and process for the preparation thereof.
US-1,008,7192 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides
The invention relates to novel compounds of the formula (I) ##STR00001## in which the R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, A.sup.1, A.sup.2, A.sup.3, A.sup.4...
US-1,008,7191 Piperidine derivative and preparation method and pharmaceutical use thereof
The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention...
US-1,008,7190 Lactones
The present disclosure relates to novel lactones such as dihydropyrrole-fused furanones, a novel palladium-catalyzed carbonylation method to make the novel...
US-1,008,7189 Process for making beta 3 agonists and intermediates
The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are...
US-1,008,7188 Benzamide imidazopyrazine Btk inhibitors
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to...
US-1,008,7187 Imidazopyridazine derivatives as PI3KB inhibitors
The present invention relates to substituted imidazopyridazine derivatives of Formula (I) ##STR00001## wherein the variables have the meaning defined in the...
US-1,008,7186 Compounds as LRRK2 kinase inhibitors
The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to...
US-1,008,7185 Fused bicylic pyridine compounds and their use as AMPA receptor modulators
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
US-1,008,7184 Dihydropyrrolopyridine inhibitors of ROR.gamma.
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful...
US-1,008,7183 Forms of methyl {4,6-diamino-2-[1 (2-fluorobenzyl)-1h-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl}methyl ...
This present invention relates to forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimi- dino-5-yl}methylcarbamate comprising...
US-1,008,7182 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds...
The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions...
US-1,008,7181 Compound as WNT signaling inhibitor, composition, and use thereof
The present invention related to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition...
US-1,008,7180 Pyrazolo-pyridine derivatives as kinase inhibitors
A series of pyrazolo[3,4-b]pyridine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, being...
US-1,008,7179 Fused tricyclic imidazole derivatives as modulators of TNF activity
A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being...
US-1,008,7178 Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor
Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent. The present...
US-1,008,7177 Process for the preparation of aclidinium bromide
A process for preparing (3R)-3-[2-Hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyc- lo[2.2.2]octane bromide (aclidinium bromide) comprises...
US-1,008,7176 3,5-dichloro,4-(3,4-(cyclo-)alkoxyphenyl)--2-carbonyloxy)ethyl)pyridine derivatives as PDE-4 inhibitors
The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4...
US-1,008,7175 Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding...
US-1,008,7174 Selectively substituted quinoline compounds
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8,...
US-1,008,7173 Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of...
Pharmaceutical compositions of the invention comprise substituted aminothiazoles derivatives having a disease-modifying action in the treatment of diseases...
US-1,008,7172 Compounds and their methods of use
Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors...
US-1,008,7171 Crystalline forms of cadazolid
The present invention relates to crystalline forms of cadazolid.
US-1,008,7170 Compound, photosensitive resin composition including the same, and color filter
A compound, a photosensitive resin composition including the compound, and a color filter manufactured using the photosensitive resin composition, the compound...
US-1,008,7169 Bicyclic PKM2 activators
Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the...
US-1,008,7168 6-substituted quinazolinone inhibitors
The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein...
US-1,008,7167 Benzofurans substituted with secondary benzamide as HCV inhibitors
Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
US-1,008,7166 Cyclic amine azaheterocyclic carboxamides
The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the...
US-1,008,7165 Fluoroquinolones and use thereof to treat bacterial infections
The present invention relates to novel fluoroquinolones, pharmaceutical compositions or medicament containing them and use thereof to treat bacterial infection.
US-1,008,7164 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct Suzuki coupling
Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl ...
US-1,008,7163 Process for preparing cyclic acetals which can be used as fuel components
The present invention relates to a process for preparing cyclic acetals having general formula (I) wherein Y and Y', equal to or different from each other, are...
US-1,008,7162 Preparation of dialkyl esters of 2,5-furandicarboxylic acid
Dialkyil esters of 2,5-furandicarboxylic acid are prepared in a process including: contacting an acid starting composition having 2,5-furandicarboxylic acid...
US-1,008,7161 Synthesis of FDCA and FDCA precursors from gluconic acid derivatives
The present invention provides methods of method of synthesizing 2,5-furan dicarboxylic acid (FDCA) and FDCA precursor molecules. The methods involve performing...
US-1,008,7160 Process for the manufacture of furural and furfural derivatives
The present invention provides a process for preparing furfural and furfural derivatives using a furfural-derived solvent.
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