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Patent # Description
US-1,009,3937 Recombinant yeast expressing rubisco and phosphoribulokinase
The invention relates to a recombinant yeast cell, in particular a transgenic yeast cell, functionally expressing one or more recombinant, in particular...
US-1,009,3936 Recombinant Bacillus subtilis for producing acetylglucosamine and construction method thereof
The present invention provides a recombinant Bacillus subtilis for producing acetylglucosamine and construction method thereof. The recombinant Bacillus...
US-1,009,3935 Generation of acyl amino acids
Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered...
US-1,009,3934 SDF-1 binding nucleic acids and the use thereof in cancer treatment
The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid...
US-1,009,3933 Compositions and methods for detecting microorganisms
Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an...
US-1,009,3932 Exon skipping technology in VCP disease
Provided herein are methods, compositions and transgenic mice useful in treating and developing treatments for VCP-associated neurodegenerative diseases.
US-1,009,3931 Apoptosis inducer
The purpose of the present invention is to provide: a composition for effectively inducing apoptosis and/or proliferation inhibition in cells; and a method in...
US-1,009,3930 Targeting WSB1 and pVHL to treat cancer
Materials and methods for treating cancer (e.g., by reducing metastasis) are provided herein. For example, materials and methods for treating cancer by...
US-1,009,3929 Modular RNA regulators and methods
This disclosure describes modular miRNA regulator molecules and methods of using modular miRNA regulator molecules. Generally, the modular miRNA regulator...
US-1,009,3928 Double-stranded RNA constructs to control insect pests
Disclosed is a dsRNA construct that relates to a method to control insect pests of the genus Helicoverpa or Heliothis double-stranded RNA interference of the...
US-1,009,3927 Reduction of off-target RNA interference toxicity
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to...
US-1,009,3926 Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric...
US-1,009,3925 Lepidopteran moth control using double-stranded RNA constructs
Disclosed is a dsRNA construct that relates to a method to control Lepidopteran moths via double-stranded RNA interference of the PBAN/Pyrokinin gene.
US-1,009,3924 Multimetric oligonucleotide compounds
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)),...
US-1,009,3923 Modulation of HSP47 expression
Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions,...
US-1,009,3922 Compositions and methods for creating altered and improved cells and organisms
The present invention provides compositions comprising randomized in-frame fusion polynucleotides and methods for introducing them into a host organism to...
US-1,009,3921 Scaffolded peptidic libraries and methods of making and screening the same
Scaffolded peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Each library includes distinct peptidic...
US-1,009,3920 Protein display
The present invention relates to methods for screening a polypeptide for desired activity against a target molecule In particular, the present invention relates...
US-1,009,3919 Method and kit for purifying nucleic acids
Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a...
US-1,009,3918 Sample collection and analysis devices
Devices and methods for collecting, processing, and analyzing a sample. A sample collection module is configured for collecting, mixing diluting, and filtering...
US-1,009,3917 Compositions, methods and kits for real-time nucleic acid analysis in live cells
The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms....
US-1,009,3916 Method for reducing or inactivating viral and microbial content in the processes for the manufacture of pancreatin
A method for the reduction or inactivation of viral and microbial content in the manufacturing of pancreatin API is disclosed. The method includes treating...
US-1,009,3915 Histidyl-tRNA synthetase-Fc conjugates
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides,...
US-1,009,3914 Xylose isomerase genes and their use in fermentation of pentose sugars
The present invention relates to eukaryotic cells which have the ability to isomerize xylose directly into xylulose. The cells have acquired this ability by...
US-1,009,3913 Methods for extracting and purifying non-denatured proteins
Materials and methods for extracting and purifying proteins are provided. For example, the materials and methods provided herein can be used for extracting and...
US-1,009,3912 Nitrile hydratase
Provided is a novel improved nitrile hydratase with improved resistance to amide compounds under high temperatures. Specifically provided is a nitrile hydratase...
US-1,009,3911 Subtilisin variants and polynucleotides encoding same
The present invention relates to subtilisin variants and methods for obtaining subtilisin variants. The present invention also relates to polynucleotides...
US-1,009,3910 Engineered CRISPR-Cas9 nucleases
Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
US-1,009,3909 Phytase
Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7...
US-1,009,3908 Recombinase polymerase amplification
The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors...
US-1,009,3907 Hetero-transglycosylase and uses thereof
The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage...
US-1,009,3906 Cytochrome C protein variants for catalyzing carbon-silicon bond formation
The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the...
US-1,009,3905 Ketoreductases
The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the...
US-1,009,3904 Reprogramming of somatic cells
The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells,...
US-1,009,3903 Production of virus-receptive pluripotent stem cell (PSC)-derived hepatocytes
The present disclosure provides methods for maturing hepatocytes comprising culturing with cyclic adenosine monophosphate and a Janus kinase inhibitor. There is...
US-1,009,3902 Human adipose tissue white and `brown-on-white` progenitors for reconstructive and metabolic therapies
Methods for preparation of prospectively identified human adipose stem cells enriched populations thereof, e.g., for therapy.
US-1,009,3901 Use of specific regulatory T-cells to induce immune tolerance
The present invention generally relates to the production of antigen-specific T regulatory cells (Tregs). Such cells can be used in therapy to minimize...
US-1,009,3900 Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has...
US-1,009,3899 Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has...
US-1,009,3898 Purification of functional human astrocytes
Compositions and methods are provided for the purification of astrocytes from biological samples or from in vitro cultures. An advantage of the methods of the...
US-1,009,3897 Generation of neuronal cells from pluripotent stem cells
The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly...
US-1,009,3896 Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
A composition of matter is provided comprising a devitalized, acellular tissue-derived scaffold seeded with differentiated cells, particularly pancreatic islet...
US-1,009,3895 Hepatic stellate cell precursors and methods of isolating same
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic...
US-1,009,3894 Method for optimizing a process for freeze drying a bacteria-containing concentrate
The present invention relates to a process for optimizing the storage stability of a freeze dried bacteria-containing product obtained from a ...
US-1,009,3893 Cell culturing system for cultivating adherent cells and liquid supply interface comprising a cell culture...
The invention relates to a liquid supply interface (62, 62', 62'', 62''') for a cell culture system for supplying cell cultures found in different cell culture...
US-1,009,3892 Isolator system and decontamination method therefor
An isolator system 1 includes: a main isolator 3 in which an aseptic state is maintained and which is for performing an aseptic operation; an incubator 4 in...
US-1,009,3891 Suspended solids separation
A method that includes clarifying a thin stillage product in a mechanical processor to produce a fine suspended solids stream and a clarified thin stillage is...
US-1,009,3890 Laundry detergent, fabric softener and cleaning formulations, systems, and water-soluble pouches
Water soluble packets containing cleaning concentrates in gel form in unit dose, ready-to-use and pouches to be reconstituted in ready-to-use cleaners and...
US-1,009,3889 Stable liquid detergent composition containing a self-structuring surfactant system
A self-structuring surfactant system. A stable liquid detergent composition containing the same. A liquid detergent composition that includes a linear alkyl...
US-1,009,3888 Solid dishwashing detergent with improved protease performance
The aim is to improve detergency, in particular on custard stains, in an essentially solid dishwashing detergent. This is accomplished with an essentially solid...
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