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Patent # Description
US-1,009,3735 Beta-klotho binding proteins
The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
US-1,009,3734 Blockade of RGMb for reducing transplantation-associated immune responses
RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.
US-1,009,3733 LRP-8 binding dual variable domain immunoglobulin proteins
The disclosure provides binding proteins that specifically bind to LRP-8 and optionally cross the blood brain barrier (BBB), localize to the brain and/or...
US-1,009,3732 Antagonists of IL-6 to prevent or treat thrombosis
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
US-1,009,3731 Anti-IL31 antibodies for veterinary use
Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced...
US-1,009,3730 Anti-interleukin-33 antibodies and uses thereof
The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
US-1,009,3729 Polypeptide, and use thereof
This invention provides a novel means that allows efficient secretion and production of a target protein in a host cell. This invention concerns a novel...
US-1,009,3728 Pharmaceutical formulations of TNF-alpha antibodies
The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are useful...
US-1,009,3727 Pan-ELR+ CXC chemokine antibodies
Antibodies are provided that specifically bind seven human ELR+ CXC chemokines. The antibodies of the invention are useful for treating various...
US-1,009,3726 Protein sustained-release injectable formulation
The present invention provides sustained-release pharmaceutical formulations for administering proteins to the eye. In particular, the invention provides...
US-1,009,3725 Anti-NGF antibodies and their use
The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of...
US-1,009,3724 Methods of treating a complement associated eye condition by administering complement factor Bb antibodies
The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the...
US-1,009,3723 Anti-tenascin C antibodies and uses thereof
There is provided antibodies or antigen-binding fragments, derivatives or variants thereof which are capable of binding to the FBG domain of tenascin-C. There...
US-1,009,3722 Nucleotide sequences, vectors and host cells
The present invention relates to fusion proteins comprising fragments from toxin A and/or toxin B of Clostridium difficile, wherein the polypeptide elicits...
US-1,009,3720 Broadly neutralizing antibody and uses thereof
The present invention relates to an exceptionally broad and potent neutralizing antibody which may comprise cross-clade neutralizing coverage of 83% at a median...
US-1,009,3719 Methods for producing stabilized human IgG2 and IgG3 antibodies
It is intended to provide highly stable variants of human antibody IgG2 and IgG3 subclasses. The present invention provides an IgG heavy chain comprising the...
US-1,009,3718 T1R taste receptors and genes encoding same
Methods are provided for identifying human and non-human primate cells which respond to sweet tastants. These methods screen for human or non-human primate...
US-1,009,3717 Chimeric antigen receptor containing a toll-like receptor intracellular domain
The present invention relates to a chimeric antigen receptor, a nucleic acid encoding the same and a cell expressing the same, and their use in manufacturing...
US-1,009,3716 Methods for treating cancer
The present invention relates to methods and materials for treating an individual with KRAS-mutated cancer or a cancer in which ROCK is inhibited independently...
US-1,009,3715 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,009,3714 Method for producing soluble FcR as Fc-fusion with inert immunoglobulin Fc-region and uses thereof
Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes a heavy chain...
US-1,009,3713 GIP-GLP-1 dual agonist compounds and methods
The present invention relates to acylated GIP analogs which have dual GIP and GLP-1 activity, and their use in the treatment of metabolic disorders.
US-1,009,3712 Immunostimulatory compositions and uses thereof
The present invention provides novel immune-stimulatory polypeptides, and methods for their use and identification.
US-1,009,3711 Interleukin-2 muteins for the expansion of T-regulatory cells
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale...
US-1,009,3710 Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia
The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with ...
US-1,009,3709 GM-CSF and IL-4 conjugates, compositions, and methods related thereto
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are...
US-1,009,3708 Interleukin-4 receptor-binding fusion proteins and uses thereof
The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that...
US-1,009,3707 Antagonists of activin-ActRIIa and uses for increasing red blood cell levels
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
US-1,009,3706 Dominant positive hnRNP-E1 polypeptide compositions and methods
Described herein are compositions relating to engineered hnRNP-E1 variant polypeptides, nucleic acids encoding such polypeptides, engineered hnRNP-E1...
US-1,009,3705 Compositions and methods for brown fat induction and activity using FNDC5
The invention provides compositions and methods for brown fat induction and activity through modulation of Fndc5 activity and/or expression. Also provided are...
US-1,009,3704 Expression and purification of CRM197 and related proteins
The present invention is directed to the cells, compositions and methods for the production of recombinant protein. In particular, the invention is directed to...
US-1,009,3703 Computationally optimized broadly reactive antigens for H1N1 influenza
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus...
US-1,009,3702 Metapneumovirus immunogens and related materials and methods
The present invention provides compositions useful to induce immune response to human metapneumovirus. Also provided are related materials and methods,...
US-1,009,3701 Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use...
Disclosed herein are compositions, cells, kits, and methods for inducing an immune response in a subject. The compositions can be used as vaccines or vaccine...
US-1,009,3700 Conformationally-preorganized, MiniPEG-containing gamma-peptide nucleic acids
The present invention relates to .gamma.-PNA monomers according to Formula I where substituent groups R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, B...
US-1,009,3699 Peptides with antimicrobial, anticancer and/or wound-healing promoting activities, pharmaceutical compositions...
A peptide with antimicrobial, anticancer and/or wound-healing promoting activities is provided. The peptide with antimicrobial, anticancer and/or wound-healing...
US-1,009,3698 Peptide having efficacy for remedying hypopigmentation and inhibiting adipogenesis, and use of same
A peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 shows a melanogenesis increment activity and an adipogenesis inhibitory activity....
US-1,009,3697 IBAT inhibitors for the treatment of liver diseases
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising...
US-1,009,3696 Nitric oxide donating carnosine compounds
The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for...
US-1,009,3695 Sterol derivative, preparation method therefor and use thereof
The present disclosure discloses a sterol derivative, a preparation method therefor and a use thereof. The sterol derivative includes a sterol compound with...
US-1,009,3694 Compounds for treating eye disorders or diseases
Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments...
US-1,009,3693 Electrochromic compound, electrochromic composition, and display element
To provide an electrochromic compound, represented by the following general formula (I): General Formula (I) where X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5,...
US-1,009,3692 Phosphines, synthesis thereof and their use in catalysis
The present invention relates to a novel class of benzimidazolyl/imidazolyl phosphine ligands, methods of preparing such ligands via a simple one-pot protocol,...
US-1,009,3691 Crystallization method and bioavailability
Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug...
US-1,009,3690 Heterocyclic selenaphosphites and process for preparation thereof
Novel heterocyclic selenaphosphites, process for preparation thereof and use thereof as ligand for employment in complexes.
US-1,009,3689 Composition containing a gold (I) complex and cancer cells
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
US-1,009,3688 Non-aqueous liquid electrolyte, electricity storage device using same, and phosphorus compound used therein
A nonaqueous electrolytic solution having an electrolyte salt dissolved in a nonaqueous solvent, containing a compound of formula (X): ##STR00001## where...
US-1,009,3687 Metal N-aminoguanidinate complexes for use in thin film fabrication and catalysis
The present patent application relates to new metal complexes having at least one N-aminoguanidinate ligand. The patent application further relates to the...
US-1,009,3686 Heteroaryl inhibitors of PDE4
The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory...
US-1,009,3685 Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
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