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Patent # Description
US-1,013,1726 Ethylene/.alpha.-olefin/non-conjugated polyene copolymer, and production process and use thereof
A novel ethylene/.alpha.-olefin/non-conjugated polyene copolymer comprising structural units derived from ethylene (A), an .alpha.-olefin (B) of 3 to 20 carbon...
US-1,013,1725 Production of high haze films using metallocene-based catalyst systems in cyclohexene
Methods for preparing metallocene-based catalyst systems containing an activator-support are disclosed. These methods are directed to contacting an...
US-1,013,1724 Process for the production of high internal phase emulsion foams
A method for polymerizing a High Internal Phase Emulsion foam including exposing a High Internal Phase Emulsion foam comprising a photoinitiator to an...
US-1,013,1723 Ligand compound, catalyst system for olefin oligomerization, and method for oligomerizing olefins using the same
The present invention relates to a compound represented by the chemical formula 1, a catalyst system for olefin oligomerization comprising the same, and a...
US-1,013,1722 Method for preparing terminal-modified conjugated diene polymer, terminal-modified conjugated diene polymer,...
This disclosure is to provide a method for preparing a terminal-modified conjugated diene polymer which achieves an extremely high compounding amount of cis-1,4...
US-1,013,1721 Polymeric acid catalysts and uses thereof
Polymers including acidic monomers and ionic monomers connected to form a polymeric backbone are disclosed. The polymers may also include, e.g., acidic-ionic...
US-1,013,1720 Method for producing fluorinated polymer particles
A method for producing particles of a fluorinated polymer (A) which has either one or both of structural units (u1) derived from tetrafluoroethylene and...
US-1,013,1719 Process for degassing and buffering polyolefin particles obtained by olefin polymerization
Process for preparing a polyolefin polymer comprising the steps of a) forming a particulate polyolefin polymer by polymerizing one or more olefins in the...
US-1,013,1718 Cross-linked hyaluronic acid grafted with dextran
A hyaluronic acid product is comprising a cross-linked hyaluronic acid and one or more dextran molecules. The hyaluronic acid is cross-linked by ether bonds,...
US-1,013,1717 Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and...
The present invention relates to topical glycosaminoglycan compositions, particularly hyaluronan compositions, that facilitate the penetration of modified...
US-1,013,1716 Method for manufacturing fungal pharmaceutical composition
The present invention provides a method for manufacturing fungal pharmaceutical composition, used for extracting a glycosaminoglycan fiber from a fungal cell...
US-1,013,1715 Cellulose particulate material
The invention relates to plant-derived cellulose-containing particles useful as rheology modifiers and to a process for preparing cellulose-containing particles...
US-1,013,1714 Protein purification using bis-tris buffer
The invention provides a two-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four...
US-1,013,1713 HER2/neu-specific antibodies and methods of using same
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as...
US-1,013,1712 Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors
The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for a tumor-associated antigen...
US-1,013,1711 Human CDR-grafted antibody and antibody fragment thereof
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4)...
US-1,013,1710 Optimized antibody variable regions
The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv...
US-1,013,1709 Nucleic acid molecules encoding monoclonal antibodies specific for IL-22
Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize...
US-1,013,1708 Methods of treating Alzheimer's disease
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes...
US-1,013,1707 Treatment of sepsis and septic shock
The technology described herein is directed to the treatment of sepsis and/or septic shock by, e.g. administering an agent that can reduce the level of...
US-1,013,1706 Anti-factor Bb antibodies
A pharmaceutical composition includes an isolated anti-Bb antibody or antigen binding portion thereof produced by a hybridoma cell line deposited under ATCC...
US-1,013,1705 Vaccines and diagnostics for the ehrlichioses
The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies,...
US-1,013,1704 Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof
The present invention provides antibodies that neutralize MERS-CoV and methods of use thereof. The invented antibody is used to treat MERS-CoV infections and...
US-1,013,1703 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,013,1702 Glucagon-GLP-1-GIP triple agonist compounds
The present invention relates to compounds which have agonist activity at the glucagon, GIP and GLP-1 receptors, and to their use in the treatment of metabolic...
US-1,013,1701 Human leucine zipper/trail recombinant polypeptides
Disclosed are recombinant polypeptides that include human TRAIL sequences as well as human leucine zipper motifs as well as polynucleotides that encode the...
US-1,013,1700 Methods for treating refractory anemia with ringed sideroblasts
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
US-1,013,1699 EphA2 T-cell epitope agonists and uses therefore
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell...
US-1,013,1698 Synthetic antimicrobial peptides
Anti-microbial compositions comprising synthetic peptides for therapeutic use are described. These compositions have found applications in treating human and...
US-1,013,1697 Vaccines against apicomplexan pathogens
The technology provided herein generally relates to novel fusion proteins suitable as human and/or animal vaccines against parasites or pathogens of the phylum...
US-1,013,1696 PCV2 ORF2 protein variant and virus like particles composed thereof
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic...
US-1,013,1695 Influenza virus vaccines and uses thereof
Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides comprising...
US-1,013,1693 Bipodal-peptide binder
The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes...
US-1,013,1692 Vasopressin-2 receptor agonists
Vasopressin-2 receptor agonists, pharmaceutical compositions thereof and methods for using the foregoing for treating diabetes insipidus, primary nocturnal...
US-1,013,1690 C6S specific transporter molecules
The present invention relates to isolated molecules, peptides, and polypeptides of specific consensus sequences or structures, and to compounds comprising or...
US-1,013,1689 Separation and purification method for vancomycin hydrochloride of high purity
Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a...
US-1,013,1688 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators
The invention relates to compounds of formula (I): wherein R.sub.1, R.sub.2, Y, R.sub.4 and R.sub.5 are as defined herein. The compounds are intermediates in...
US-1,013,1687 Raman tag
A method of forming a probe, wherein the method includes converting cholenic acid into a compound with a terminal alkyne group, wherein the converting the...
US-1,013,1686 Compositions and methods for altering second messenger signaling
The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the...
US-1,013,1685 Di- and triphosphate prodrugs
Compounds which can be used as prodrugs, in particular nucleoside diphosphate and triphosphate prodrugs, and a method for producing these compounds. The aim is...
US-1,013,1684 Process for the preparation of macrolide antibacterial agents
Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.
US-1,013,1683 TH-302 solid forms and methods related thereto
The present invention provides a new method for making TH-302 and solid forms thereof. The compound in its solid form is an effective anti-cancer agent and may...
US-1,013,1682 Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
Cell binding agent-drug conjugates comprising hydrophilic linkers, and methods of using such linkers and conjugates are provided.
US-1,013,1681 Aminophosphinic derivatives that can be used in the treatment of pain
The present invention relates to a compound of the following general formula (I): R.sub.1--NH--CH(R.sub.2)--P(.dbd.O)(OR.sub.3)--CH.sub.2--C(R.sub.4)(R.sub- ...
US-1,013,1680 Group 4 metal element-containing alkoxy compound, preparing method thereof, precursor composition including the...
The present disclosure provides a Group 4 metal element-containing novel alkoxy compound, a method of preparing the Group 4 metal element-containing alkoxy...
US-1,013,1679 Substituted dihydropyrrolopyrazole compound
Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: ##STR00001## wherein L.sup.1 is an optionally substituted...
US-1,013,1678 Method for producing branched oligoarylsilanes
Branched oligoarylsilanes of general formula (I) X.sub.mQ.sub.k-SiAr.sub.n--R).sub.3].sub.2 (I). A method of preparation of branched oligoarylsilanes is that a...
US-1,013,1677 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridine and therapeutic uses thereof
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
US-1,013,1676 Compounds, compositions and methods
The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
US-1,013,1675 Tricyclic DLK inhibitors and uses thereof
The invention relates to compounds of formula (I) and salts thereof: ##STR00001## wherein ring A and R.sup.1-R.sup.2 have any of the values defined in the...
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