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Patent # Description
US-1,013,1674 Process for preparing Substituted Indole Compounds
The present invention is directed to a process for preparing Substituted Indole Compounds of Formula (I): wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as...
US-1,013,1673 Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the...
The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an...
US-1,013,1672 Therapeutic or prophylactic agent for biliary diseases
A therapeutic or prophylactic agent for biliary tract diseases includes as an effective component a specific compound having a morphinan skeleton represented by...
US-1,013,1671 Organic compounds
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or...
US-1,013,1670 Bicyclic heteroaryl derivatives as CFTR potentiators
The present invention relates to 1,3-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine derivatives, 5,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazin-4-amine...
US-1,013,1669 Pyrazolopyrimidine compounds
The present invention is directed to pyrazolopyrimine compounds or pharmaceutically acceptable salts which are inhibitors of PDE4 isozymes, especially with a...
US-1,013,1668 Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1
Described herein, inter alia, are compositions and methods of using the same for modulating the activity of Ire1 using for example, substituted imidazopyrazine...
US-1,013,1667 Substituted tricyclic compounds as FGFR inhibitors
The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are...
US-1,013,1666 Heterocyclic morphinan derivatives and use thereof
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-1,013,1665 Processes for producing diazabicyclooctane compounds
A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same: ##STR00001##
US-1,013,1664 Inhibitors of lysine specific demethylase-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
US-1,013,1663 Chemical compounds
The specification relates to compounds of Formula (I): ##STR00001## and to pharmaceutically acceptable salts thereof, to processes and intermediates used for...
US-1,013,1662 Pesticidally active tetracyclic derivatives with sulfur containing substituents
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and...
US-1,013,1661 High-solubility acetone-added pyrroloquinoline quinone salt
There are provided an alkali metal salt of 5-hydroxy-4-oxo-5-(2-oxopropyl)-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,- 7,9-tricarboxylic acid, a method for...
US-1,013,1660 Tetrahydro-azepinoquinolines as agonists of the 5-HT.sub.2C receptor
Certain tetrahydro-azepinoquinolines of structural formula I are agonists of the mammalian 5-HT.sub.2c receptor, and, in particular, are selective agonists of...
US-1,013,1659 Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and...
Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.
US-1,013,1658 Anti-alphavbeta1 integrin compounds and methods
Provided herein, inter alia, are methods and compositions for inhibiting .alpha.v.beta.1 integrin and for treating fibrosis.
US-1,013,1657 Bromodomain inhibitors
The present invention provides for compounds of formula (I). wherein R.sup.x, R.sup.y, R.sup.x1, L.sup.1, G.sup.1, A.sup.1, A.sup.2, A.sup.3, and A.sup.4 have...
US-1,013,1656 Organic thin film transistor, method of manufacturing organic thin film transistor, organic thin film...
An object of the present invention is to provide an organic thin film transistor that has an organic semiconductor film manufactured by using a compound having...
US-1,013,1655 Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists
The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically...
US-1,013,1654 Pyrazole compounds and methods of use thereof
The present invention comprises compounds of Formula I and their use in the inhibition of cell proliferation in therapeutic treatments. Pharmaceutical...
US-1,013,1653 Heterocyclic compound
The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the...
US-1,013,1652 Pyrimidinyloxy benzene derivatives as herbicides
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q, Z, R.sup.2, R.sup.3 and m are as...
US-1,013,1651 [7,6]-fused bicyclic antidiabetic compounds
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
US-1,013,1650 Alpha-helix analog having triazine-piperazine backbone and method for preparing same
The alpha-helix mimetic containing a triazine-piperazine scaffold is provided. The alpha-helix mimetic compound can mimic efficiently the alpha-helix structure...
US-1,013,1649 Bicyclic compounds as pest control agents
The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to...
US-1,013,1648 Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
US-1,013,1647 Chromene derivatives substituted by alkoxide as inhibitors of the TCR-Nck interaction
The present invention relates to a group of compounds of formula (I) containing a chromene nucleus: ##STR00001## and that present the capacity to inhibit the...
US-1,013,1646 Aromatic sulfonium salt compound, photoacid generator, resist composition, cationic polymerization initiator,...
Provided are: an aromatic sulfonium salt compound which exhibits low corrosion to a substrate and excellent photolithographic characteristics and is thus useful...
US-1,013,1645 Benzofurans substituted with primary benzamide as HCV inhibitors
Compounds of Formula (I), including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
US-1,013,1644 Aryl sultam derivatives as RORc modulators
Compounds of the formula I: ##STR00001## or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X.sup.1, X.sup.2, X.sup.3, X.sup.4, Y, Z, A,...
US-1,013,1643 Tizoxanide carbamate and pharmaceutical use thereof
The invention relates to a tizoxanide carbamate compound of Formula I and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and their...
US-1,013,1642 Aldosterone synthase inhibitors
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2 and R.sup.3 are as defined...
US-1,013,1641 Method for producing TDI-trimerisates with high purity
The invention relates to a novel method for producing polyisocyanurates comprising isocyanate groups, based on 2,4- and 2,6-toluylene diisocyanate (TDI) and to...
US-1,013,1640 Anti-inflammatory agents
Disclosed are novel compounds that are useful in regulating the expression of interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1), and their...
US-1,013,1639 Formulations of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4methylcyclohexylamino)-pyrim- idine-5-carboxamide
Provided are pharmaceutical compositions and dosage forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide, or...
US-1,013,1638 Synthesis of AZO intermediate
A synthesis for an azo intermediate, 5,5'-azobis(4-chloropyrimidine) is disclosed. 5,5'-azobis(4-chloropyrimidine) is a relatively stable azo compound in that...
US-1,013,1637 Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases
Disclosed are compounds of the class of 2-phenylacetamides that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9),...
US-1,013,1636 Process for the preparation of Enzalutamide
The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave...
US-1,013,1635 Compositions and methods of using the compositions for plaque softening
Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of...
US-1,013,1634 Method of treating pain
The instant application discloses methods of treating, reducing, or preventing pain in a mammal, which may include administering a compound capable of...
US-1,013,1633 Cationic lipid
The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of...
US-1,013,1632 Dopant for organic optoelectronic device, organic optoelectronic device and display device
The present invention relates to a dopant for an organic optoelectronic device represented by Chemical Formula 1, and to an organic optoelectronic device and a...
US-1,013,1631 Malassezin and analogs thereof as skin brightening agents
The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention...
US-1,013,1630 Process for preparing (3RS)-3-[(2SR)-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylp- ...
The present invention relates to an efficient and environmentally friendly process for preparing ...
US-1,013,1629 Process for producing ajoene
The present invention relates to a process for producing ajoene from allicin via a polymeric substrate, comprising the steps of heating allicin or an allicin...
US-1,013,1628 2,2'-diaminobiaryls having a phthaloyl group or succinoyl group
An electrochemical treatment of differently protected aniline or napthylamine results in the preparation of unsymmetrical 2, 2'-diaminebiaryls provided with...
US-1,013,1627 Heterodimers of glutamic acid
Compounds of Formula (Ia) ##STR00001## wherein R is a C.sub.6-C.sub.12 substituted or unsubstituted aryl, a C.sub.6-C.sub.12 substituted or unsubstituted...
US-1,013,1626 3-aryl propiolonitrile compounds for thiol labeling
The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile...
US-1,013,1625 Method for preparing 3-carbamoymethyl-5-methylhexanoic acid in recycling way
The present invention provides a method for recycling 3-carbamoylmethyl-5-methylhexanoic acid from 3-carba carbamoylmethyl moymethyl-5-methylhexanoic acid...
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