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Patent # Description
US-1,013,7203 HER2 aptamer-anticancer drug complex for cancer cell chemotherapy
A method of manufacturing a complex for cancer cell chemotherapy comprises an aptamer preparation step of preparing a nucleic acid aptamer having an aptamer...
US-1,013,7202 Antibody-drug conjugates and immunotoxins
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically...
US-1,013,7201 Process for formulating an anionic agent
Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an...
US-1,013,7200 Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty...
US-1,013,7199 Thiolated hyaluronan-based hydrogels cross-linked using oxidized glutathione
The invention provides methods, compositions and kits relating to hyaluronan based matrices using oxidized glutathione as a crosslinking agent.
US-1,013,7198 Lipid layer forming composition for administration onto a surface of a living organism
A lipid layer forming composition comprises a volatile silicone oil of a boiling point above 180.degree. C., a polar lipid, optionally a C.sub.2-C.sub.4...
US-1,013,7197 Process for preparing an immunoglobulin preparation
The present invention relates to the use of proline for reducing the viscosity of a protein preparation.
US-1,013,7196 Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. In...
US-1,013,7195 Therapy involving antibodies against Claudin 18.2 for treatment of cancer
The present invention generally provides a therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, in particular...
US-1,013,7194 Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith
Immunogenic influenza hemagglutinin-derived peptide conjugates described herein induce a specific therapeutic antibody response against influenza virus. The...
US-1,013,7193 Methods for treating or preventing asthma by administering an IL-4R antagonist
The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise...
US-1,013,7192 Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about...
US-1,013,7191 Methods and compositions for inducing protective immunity against human immunodeficiency virus infection
Compositions, vaccines and methods for inducing protective immunity against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine...
US-1,013,7190 Nucleic acid molecules encoding ferritin-hemagglutinin fusion proteins
Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers...
US-1,013,7189 Influenza virus vaccines and uses thereof
Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.
US-1,013,7188 Cell lines for virus production and methods of use
Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of...
US-1,013,7187 Recombinant subunit dengue virus vaccine
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present...
US-1,013,7186 Compositions and methods for live, attenuated alphavirus formulations
Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition...
US-1,013,7185 PAP peptide analogues
The application provides a polypeptide comprising the sequence SLMTNLAAL (SEQ ID NO: 8), Ser 13 to Leu 21 of amino acid sequence shown in FIG. 1 or SEQ ID No 1,...
US-1,013,7184 Scaffolds for cell transplantation
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold...
US-1,013,7183 Peptide compositions having 4 linked CTL epitopes and uses thereof
This invention provides a cancer antigen peptide that can be administered to a wide range of cancer patients in the form of a peptide vaccine for cancer without...
US-1,013,7182 Cancer vaccines and vaccination methods
Compositions of multipeptide vaccines comprising at least seven tumor associated antigens, compositions of antigen presenting cell (e.g., dendritic cell) based...
US-1,013,7181 Isolated donor MHC-derived peptide and uses thereof
The invention relates to an peptide derived from a polymorphic region of donor MHC class II molecules which induces tolerance and thus prevents transplant...
US-1,013,7180 Methods for regulating protein function in cells in vivo using synthetic small molecules
Methods and compositions for the rapid and reversible destabilizing of specific proteins in vivo using cell-permeable, synthetic molecules are described.
US-1,013,7179 Composition and method of preparation of protease microparticulate slow release preparation
Compositions containing microparticles loaded with one or protease enzymes and optionally auxiliary therapeutic agents and methods of treating conditions such...
US-1,013,7178 Dental gel composition of papain for the atraumatic treatment of caries and method of preparing same
A papain dental gel composition is disclosed for the atraumatic treatment of caries which comprises papain with a final activity of at least 3,000 U/mg, wherein...
US-1,013,7177 Methods and compositions used in treating inflammatory and autoimmune diseases
Methods of treating neuroinflammation by administration of a selective protein C activator, such as recombinant human WE thrombin and optionally one or more of...
US-1,013,7176 Compositions and methods for treating MPSI
A vector having an expression cassette having a hIDUA gene having a sequence of SEQ ID NO: 1 or a sequence at least about 95% identical thereto which encodes a...
US-1,013,7175 Antimicrobial agents
The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of...
US-1,013,7174 Methods and materials for treating cancers that express reduced levels of wild-type p53 polypeptides
This document relates to methods and materials involved in modulating deubiquitinases (e.g., USP10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor...
US-1,013,7173 Antiviral activity of Gas6 inhibitor
Compositions and methods are provided for treating viral infection in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits...
US-1,013,7172 Administration regime
The invention relates to a novel administration regime useful in the treatment of diseases or conditions where administration of insulin will be of benefit, as...
US-1,013,7171 Methods of treatment using a pentapeptide derived from the C-Terminus of Glucagon-Like Peptide 1 (GLP-1)
Methods of treating obesity, metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes using a pentapeptide, LVKGRamide, derived from the C-terminus...
US-1,013,7170 Lipidated incretin receptor ligand human immunoglobulin Fc-region fusion polypeptides
Herein is reported a fusion polypeptide comprising i) one, two, three or four incretin receptor ligand polypeptides, and ii) one human immunoglobulin Fc-region,...
US-1,013,7169 Compositions and uses thereof
The present invention provides a composition for stimulating hair growth in a mammal comprising a modified osteopontin polypeptide in which an RGD domain is...
US-1,013,7168 Veterinary decorin compositions and use thereof
The present invention relates to veterinary decorin compositions and methods of their production.
US-1,013,7167 Methods comprising desmopressin
The present disclosure is directed to reducing nocturnal voids by administering a dose of desmopressin over a minimum treatment period compared to before...
US-1,013,7166 Compositions and methods for affecting movement of contaminants, bodily fluids or other entities, and/or...
Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable...
US-1,013,7165 Factor H for the treatment of chronic nephropathies and production thereof
The invention relates to the use of Factor H for the manufacture of a medicament to treat both chronic nephropathies which are not causally associated with...
US-1,013,7164 Dietary supplement compositions
This document provides dietary supplement compositions. For example, dietary supplement compositions having an acetylcholinesterase inhibitor (e.g., huperzine...
US-1,013,7163 Melaleuca quinquenervia extracts and uses of the same
A Melaleuca quinquenervia extract and its uses are provided. The extract is extracted by a first polar solvent, wherein the first polar solvent is a C3-C6...
US-1,013,7162 Gastroprotective extracts of Sonchus oleraceus L.
The gastroprotective extracts of S. oleraceus L. are ethanol extracts (including the initial ethanol extract and serial extractions of the marc in ethanol),...
US-1,013,7161 Medical cannabis lozenges and compositions thereof
A method for optimizing the therapeutic effects provided by CBD on the one hand, and the psychoactive effects provided by THC on the other hand, in a sublingual...
US-1,013,7160 Use of Humulus japonicus extract for treating obesity or hyperlipidemia
A functional health food containing Humulus japonicus extract as an active ingredient for preventing or improving metabolic disorders or for weight loss, a...
US-1,013,7159 Boehmeria extract and its use in treating liver diseases
A method for treating liver fibrosis. The method includes administering to a subject suffering from liver fibrosis a pharmaceutically active extract obtained...
US-1,013,7158 Use of photosynthesis to rebalance ischemia bioenergetics
Compositions and methods are provided for photosynthetic correction of metabolic imbalances that occur in ischemic conditions. In the methods of the invention,...
US-1,013,7157 Treatment of obesity, the metabolic syndrome, type 2 diabetes, cardiovascular diseases, dementia, alzheimer's...
A product for use in the treatment of obesity, the metabolic syndrome, type 2 diabetes, cardiovascular diseases, dementia, alzheimers disease and inflammatory...
US-1,013,7156 Composition comprising neural cell and elastin-like polypeptide for treating Parkinson's disease
The present invention relates to a composition including neural cells and an elastin-like polypeptide for treating Parkinson's diseases. More particularly, the...
US-1,013,7155 Compositions and methods for inhibition of lineage specific antigens
Disclosed herein are methods of administering an agent targeting a lineage-specific cell-surface antigen and a population of hematopoietic cells that are...
US-1,013,7154 Methods and compositions for expanding long-term hematopoietic stem cell populations
The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the...
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