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Patent # Description
US-1,013,8527 Method for monitoring differentiation into cardiac muscle cells
A method for monitoring differentiation into cardiac muscle cells includes keeping, in an alive state, cells into which a reporter gene of luminescent protein...
US-1,013,8526 Molecular markers associated with stem canker resistance in soybean
The present invention provides methods and compositions for the identification and selection of loci modulating phenotypic expression of a stem canker...
US-1,013,8525 Compositions and methods to detect atopobium vaginae nucleic acid
The disclosed invention include nucleic acid oligomers that may be used as amplification oligomers, including primers, as capture probes for sample preparation,...
US-1,013,8524 Synthetic nucleic acid control molecules
The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic...
US-1,013,8523 Cancer biomarker and diagnostic
The application discloses new biomarkers and methods useful in the diagnosis, prognosis and/or monitoring of, or as a therapeutic or research target for, solid...
US-1,013,8522 Identification of cattle at risk of high altitude pulmonary hypertension
Provided herein are methods and compositions for determining the susceptibility of cattle to High Altitude Pulmonary Hypertension. Also provide are kits and...
US-1,013,8521 Treatment and diagnosis of epigenetic disorders and conditions
The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present...
US-1,013,8520 Diagnostic miRNA markers for Alzheimer
The invention relates to methods for diagnosing Alzheimer's Disease (AD) with miRNA markers. Diagnosis of AD Towards the identification of biomarkers for...
US-1,013,8519 Universal sanger sequencing from next-gen sequencing amplicons
Described herein are methods, compositions and kits directed to amplification of nucleic acids suitable for both next generation sequencing (NGS) and a second...
US-1,013,8518 Annealing control primer and its uses
The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all...
US-1,013,8517 Manipulation of microparticles in microfluidic systems
An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device...
US-1,013,8515 Illumination of integrated analytical systems
An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for...
US-1,013,8514 Modified nucleosides or nucleotides
Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3'-hydroxy protecting groups. Also provided herein are...
US-1,013,8513 Method and device for amplifying and detecting gene using graphene heater
Provided is a gene amplifying and detecting device. The gene amplifying and detecting device includes: a gene amplifying chip including a chamber formed...
US-1,013,8512 Nucleic acid processing of a nucleic acid fragment with a triazole linkage
A method of nucleic acid processing that comprises providing an adapted nucleic acid fragment having a triazole linkage therein, and transcribing the adapted...
US-1,013,8511 Arrays of microparticles and methods of preparation thereof
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized...
US-1,013,8510 Dual labeling methods for measuring cellular proliferation
The present invention provides a method for measuring cellular nascent nucleic acid synthesis by dual pulse labeling of nucleic acid. The first pulse labeling...
US-1,013,8509 Method for generating a three-dimensional nucleic acid containing matrix
Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
US-1,013,8508 Method for measuring modified nucleobase using guide probe, and kit therefor
The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target nucleic...
US-1,013,8507 Manufacturing methods for production of RNA transcripts
Described are methods for production of RNA transcripts using a non-amplified, linearized DNA template in an in vitro transcription reaction. Enzymatic 5'...
US-1,013,8506 Enzymatic production of D-tagatose
The current disclosure provides a process for enzymatically converting a saccharide into tagatose. The invention also relates to a process for preparing...
US-1,013,8505 Process for the production of organic compounds from plant species
This invention relates to a process for the production of fermentable C5-C6 sugars from oleaginous herbaceous plants comprising the steps of: a) mechanically...
US-1,013,8504 Production of malonyl-CoA derived products via anaerobic pathways
The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as...
US-1,013,8503 Transaminase reactions
The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
US-1,013,8502 Method for producing oil containing polyunsaturated fatty acid using lipase
A method for lowering saturated fatty acid content, the method comprising concentrating polyunsaturated fatty acid using a lipase having low reactivity for the...
US-1,013,8501 Method for preparing diglyceride using bubble column reactor
Disclosed is a method for synthesizing diglyceride using a bubble column reactor. The method comprises the steps of: an immobilized enzyme is placed on the...
US-1,013,8500 D-lactic acid-producing strain and use thereof
The present invention relates to a method for preparing a D-lactic acid-producing strain modified to inhibit L-lactate dehydrogenase (L-LDH) activity and to...
US-1,013,8499 Methods for improving the efficiency of simultaneous saccharification and fermentation reactions
The present disclosure is directed, in a first aspect, to the use of inverting beta-xylosidase enzymes to reduce byproduct formation and increase the yield of...
US-1,013,8498 Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in...
US-1,013,8497 Agents for improved delivery of nucleic acids to eukaryotic cells
New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in...
US-1,013,8496 Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV
The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to...
US-1,013,8495 Bio-production of lentiviral vectors
The present disclosure provides a method of generating a stable producer cell line. The generation of stable producer cell lines, such as those provided in...
US-1,013,8494 Whole expressed cell as antigen carrier, and use thereof in preparing vaccine or diagnostic agent, and...
A mammalian cell co-transfect with an expression plasmid comprising T7 promoter and an open reading frame (ORF) of target antigen, and a vT7 recombinant...
US-1,013,8493 Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins
Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to...
US-1,013,8492 Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics...
Methods and materials for modulating low-nitrogen tolerance levels in plants are disclosed. For example, nucleic acids encoding low nitrogen ...
US-1,013,8491 Protein having glycoalkaloid biosynthetic enzyme activity and gene encoding the same
An object of the present invention is to provide DNA of a glycoalkaloid biosynthetic enzyme of a solanaceous plant (Solanaceae) such as a potato. The present...
US-1,013,8490 Transformed plants tolerant to herbicides due to overexpression of prephenate dehydrogenase and...
The present invention relates to transformed plants, in particular transformed plants producing larger amounts of plastoquinones, tocotrienols and tocopherols...
US-1,013,8489 Cyanobacterial strains capable of utilizing phosphite
The invention provides genetically modified cyanobacterial cells that are capable of utilizing phosphite as a primary phosphorus source, and can out-compete...
US-1,013,8488 Cancer vaccine for dogs
The present invention provides an immunogenic composition comprising a nucleic acid that comprises a sequence encoding a dog telomerase deprived of telomerase...
US-1,013,8487 Aptamers against glioma cells
Provided are aptamers able to bind to ligands associated with cancer cells. The ligands may particularly be associated with brain cancers, such as gliomas. The...
US-1,013,8486 Inhibitors of DEK protein and related methods
The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of...
US-1,013,8485 Neutral nanotransporters
Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified...
US-1,013,8484 Targeting microRNAs for metabolic disorders
Described herein are compounds comprising modified oligonucleotides that are complementary to miR-103 and/or miR-107 and methods of treating diseases and...
US-1,013,8483 Transferrin/transferrin receptor-mediated siRNA delivery
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in...
US-1,013,8482 Compositions for modulating C9ORF72 expression
Disclosed herein are compositions and methods for reducing expression of C9ORF72 mRNA and protein in an animal. Such methods are useful to treat, prevent,...
US-1,013,8481 miRNAs useful for identifying targets associated with cancer
Several miRNAs are described that are useful in diagnosing and treating prostate cancer, or pancreatic cancer. The miRNAs bind with targets that are associated...
US-1,013,8480 Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present...
US-1,013,8479 Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are...
US-1,013,8478 Antibody libraries
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically...
US-1,013,8477 Method of producing secretable antibodies by expression in saccharomyces cerevisiae
The invention relates to a method for the production and non-covalent surface display of antibodies and derived fragments as well as molecule libraries based...
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