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Patent # Description
US-1,013,8476 Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
US-1,013,8475 Methods and compositions for isolating small RNA molecules
The present invention concerns the use of methods and compositions for the isolation of small RNA molecules (100 nucleotides or fewer), such as microRNA and...
US-1,013,8474 Scavenger receptor uptake for fabry disease enzyme replacement therapy
The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments,...
US-1,013,8473 Thermostable protease variants
The present invention relates to proteases having at least 75% identity to a protease derived from Thermoascus aurantiacus and comprises at least one...
US-1,013,8472 Engineered nucleic-acid targeting nucleic acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
US-1,013,8471 Insertion of charge in the hydrophobic interior of proteins as a strategy for engineering pH-sensitive switches
Methods are provided for engineering non-naturally occurring proteins comprising artificial pH-sensitive conformational switches that respond to a change in pH...
US-1,013,8470 Mutated enzyme having dehydrogenase activity and use thereof
The object is to provide a novel enzyme exhibiting cholesterol dehydrogenase activity. Provided is a mutant enzyme having an amino acid sequence of a...
US-1,013,8469 Synthetic peptide and use thereof
Provided are a synthetic peptide that induces the reprogramming of a differentiated cell, a reprogramming-inducing pharmaceutical composition that contains this...
US-1,013,8468 Method for differentiation of pluripotent stem cells into multi-competent renal precursors
This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal...
US-1,013,8467 Medium for high performance mammalian fed-batch cultures
The present invention relates to new serum- and protein-free culture media. These media are high performance culture media, which notably improve mammalian...
US-1,013,8466 Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g.,...
US-1,013,8465 Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators
The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In...
US-1,013,8464 Use of apoptotic cells ex vivo to generate regulatory T cells
Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell ("APC"), has...
US-1,013,8463 Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from...
US-1,013,8462 Natural killer cell lines and methods of use
This invention relates to a natural killer cell line termed NK-92 and to NK-92 cell lines that have been modified by transfection with a vector to confer...
US-1,013,8461 Animal protein-free media for cultivation of cells
The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also...
US-1,013,8459 Bacterial strain Rhodococcus aetherivorans VKM Ac-2610D producing nitrile hydratase, method of its cultivation...
The invention relates to a bacterial strain belonging to the genus Rhodococcus which is a producer of a nitrile hydratase. The invention also relates to a...
US-1,013,8458 Magnetic lysis method and device
A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a...
US-1,013,8457 Tissue processing apparatus and method for processing adipose tissue
A method for processing biological material containing stringy tissue in a container having a tissue collector disposed in a tissue retention volume on one side...
US-1,013,8456 Cell concentration adjustment device, and automatic subculture system using same
A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a...
US-1,013,8455 Incubator chamber
A incubator chamber comprises a base, lid and plurality of trays, each of which are stackable upon one another in an open or closed configuration. A clamp could...
US-1,013,8454 Culture container
A cell-culture container includes a container main body and a presser member. The container main body has a recessed part for containing a cell-culture...
US-1,013,8453 Cell culture array system for automated assays and methods of operation and manufacture
A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for...
US-1,013,8452 Object-holding device
An object-holding device includes a container, a plate, and a dispersing mechanism. The container is configured to store a liquid, and includes an upper opening...
US-1,013,8451 Cell culture dish supporting simultaneously juxtaposed and separated cultures
The present invention relates to a novel culturing apparatus (assembly) which can be termed a cell culture dish. More particularly, the present invention is a...
US-1,013,8450 Cell culture device
An automatic culture device which employs closed-system culture vessels and in which, when a passage part (2) and a rotational valve mechanism (3) are...
US-1,013,8449 Reduced calorie beverage or food product and process and apparatus for making same
The invention relates to a process for preparing a reduced calorie beverage or food product employing fermentation of a plant-derived juice or liquid and...
US-1,013,8448 Deactivation wipe kit
A hazardous drug deactivation wipe kit includes a first pouch having a one-way valve coupled to an end thereof, a second pouch, and a third pouch. The first...
US-1,013,8447 Fragrance intensity enhanced products and methods therefor
Disclosed are products incorporating fragrance-enhancing compositions, methods for increasing the fragrance intensity of fragrance-containing products, and...
US-1,013,8446 Cleaning product
A cleaning product having a spray dispenser and a cleaning composition suitable for spraying and foaming, the composition housed in the spray dispenser wherein...
US-1,013,8445 Cleaning product
A cleaning product having a spray dispenser and a cleaning composition suitable for spraying, the composition housed in the spray dispenser wherein the...
US-1,013,8444 Bacteria and enzymes produced therefrom and methods of using same
A bacteria referred to here as Bacillus subtilis 6A-1 is provided, compositions thereof and processes for use of the bacteria, spores, cells, extracts and...
US-1,013,8443 Cleaning composition with rapid foam collapse
An aqueous cleaning composition including: a surfactant; a first compound that is immiscible with water and has Hansen solubility parameters of 10 ...
US-1,013,8442 Outdoor cleaning system concentrates
An outdoor cleaning concentrate composition having improved dirt and stain cleaning properties on outdoor surfaces, that is less corrosive and capable of being...
US-1,013,8441 Fragrance compositions and uses thereof
The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in...
US-1,013,8440 Shock absorber oil composition
A shock absorber oil composition of the invention includes a base oil: (A) at least one of phosphate, amine phosphate salt, phosphite and amine phosphite salt;...
US-1,013,8439 Lubrication material using self-dispersed crumpled graphene balls as additives in oil for friction and wear...
A method for forming a lubrication material using self-dispersed crumpled graphene balls as additives in a lubricant base fluid for friction and wear reduction....
US-1,013,8438 Low sulfur marine distillate fuel trunk piston engine oil composition
The present invention generally relates to a trunk piston engine oil composition designed for use with low sulfur distillate fuel where the lubricating oil has...
US-1,013,8437 Water-soluble lubricant oil
The present invention provides a water-soluble lubricating oil including a water-soluble base (A) and a corrosion inhibitor (B). The water-soluble base (A)...
US-1,013,8436 System and method for converting food waste into fuel
A system for converting food waste into fuel includes at least one thermal decomposition reactor. The at least one thermal decomposition reactor is configured...
US-1,013,8435 Renewable diesel and jet fuel from microbial sources
The invention provides methods of manufacturing alkanes from triglyceride oils produced through fermentation of oil-bearing microbes. The processes provided...
US-1,013,8434 Surface treatment method and device treated thereby
A surface treatment method includes: contacting a substrate with a treatment material, the substrate comprising a metallic element, the treatment material...
US-1,013,8433 Method and apparatus for purifying a mixture comprising oil and wax
The present invention relates to a method for fractionating a crude mixture comprising at least one oil and at least one wax, which comprises the following...
US-1,013,8432 Process for removing metals from hydrocarbons
Mercury is removed from a mercury-containing hydrocarbon fluid feed by utilizing ionic liquids. The mercury-containing hydrocarbon fluid feed is contacted with...
US-1,013,8431 Method and reactor for cracking hydrocarbon
A method for cracking hydrocarbon, comprises: providing steam and hydrocarbon; and feeding steam and hydrocarbon into a reactor accessible to hydrocarbon and...
US-1,013,8430 Conversion of lipids into olefins
A method of converting lipids to useful olefins includes reacting a mixture of lipids and a reactant olefin with microwave irradiation in the presence of...
US-1,013,8429 Method for starting up a Fischer Tropsch process
The invention relates to a method to start up a Fischer-Tropsch process. A catalyst with a latent activity is used. The catalyst comprises titania, cobalt,...
US-1,013,8428 Catalyst assisted conversion of biomass to bio-oil
The present disclosure relates to a process for the production of crude bio-oil which involves heating a mixture of biomass slurry and a mixed catalyst system...
US-1,013,8427 Separation of hydrocarbons from particulate matter using salt and polymer
Separating hydrocarbon from compositions including hydrocarbon and solids such as oil sands, oil sands by products, asphalt compositions, etc. includes treating...
US-1,013,8426 Combined hydrothermal liquefaction and catalytic hydrothermal gasification system and process for conversion of...
A combined hydrothermal liquefaction (HTL) and catalytic hydrothermal gasification (CHG) system and process are described that convert various ...
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