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Patent # Description
US-1,015,0996 Quantification of adaptive immune cell genomes in a complex mixture of cells
A relative representation of adaptive immune cells in a biological sample is quantified using multiplex PCR and sequencing of adaptive immune cells, control...
US-1,015,0995 Transposition of native chromatin for personal epigenomics
Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated...
US-1,015,0994 Modular flow cells and methods of sequencing
Modular flow cells, devices with modular flow cells, and methods of sequencing using modular flow cells, as well as systems and kits including modular flow...
US-1,015,0993 Macromolecule positioning by electrical potential
Provided herein is technology relating to depositing and/or placing a macromolecule at a desired site for an assay and particularly, but not exclusively, to...
US-1,015,0992 Substrates and methods useful in sequencing
A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling...
US-1,015,0991 Methods for beaming
Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination...
US-1,015,0990 Ribonucleotide tag nucleic acid detection
The present application provides polynucleotides comprising 5'-tails with sequence segments useful for the detection of target nucleic acid sequences, and...
US-1,015,0989 Fibrosis susceptibility IL22RA2 gene and uses thereof
The present invention discloses the identification of a fibrosis susceptibility gene locus, the IL22RA2 gene locus, which can be used for detecting...
US-1,015,0988 Multiplexed in situ molecular analyses and programmable molecular probes for regulated single amplification
The present invention generally relates to methods for detecting a target in a sample; methods for modulating the reporting intensity of a labeled target in a...
US-1,015,0987 Labeled circular DNA molecules for analysis of DNA topology, and topoisomerases and for drug screening
The present invention provides labeled circular plasmid DNA molecules for studying DNA topology and topoisomerases. The molecules of the present invention also...
US-1,015,0986 Biosensors comprising concatemeric nucleic acid molecules
The present application relates to biosensors, for example comprising an high-molecular weight, tandem repeating, structure-switching nucleic acid aptamers...
US-1,015,0985 Methods of depleting a target molecule from an initial collection of nucleic acids, and compositions and kits...
Provided are methods of depleting a target nucleic acid from an initial collection of nucleic acids. Aspects of the methods include contacting the initial...
US-1,015,0984 Tyrosine kinase biosensors and methods of use
Disclosed are compositions and methods for measuring tyrosine kinase activity.
US-1,015,0983 Method for measuring indoxyl sulfuric acid
It is an object of this invention to provide a simple measurement method capable of detecting indoxyl sulfuric acid in a sample rapidly and at high sensitivity....
US-1,015,0982 Microbial ecology shift assay
The disclosure provides assay methods for characterizing the effects of an agent on a microbiome of a subject. Moreover, the disclosure provides methods for...
US-1,015,0981 Method of determining an analyte concentration
A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and...
US-1,015,0980 Use of CO.sub.2 to deactivating a cellulolytic microorganism used in the biochemical conversion of...
The invention concerns a process for deactivating a cellulolytic microorganism enabling the production of an enzymatic cocktail, said cocktail being used...
US-1,015,0979 Purification of secreted polysaccharides from S. agalactiae
The invention relates to bacterial mutants, particularly from Streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the...
US-1,015,0978 Method of manufacturing cellulosic sugar from biomass through effective separation of impurities and sugar
The present invention relates to a method of producing cellulosic sugar from biomass by effective impurity removal and sugar separation, and more particularly...
US-1,015,0977 Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway....
US-1,015,0976 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol,...
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in...
US-1,015,0975 Methods and compositions for producing hydrocarbons
Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
US-1,015,0974 Solvent production
The invention relates to a process and system for the production of a solvent using monophasic solventogenic Clostridia in a single stage process. More...
US-1,015,0973 Apparatus and method for separating and refining product manufactured by microbial fermentation by using adsorbent
The present invention relates to an apparatus and a method for fermenting, separating, and refining a product, which is produced by cultivating a microorganism....
US-1,015,0972 Composition to enhance immunity
The present invention provides a composition for enhancing immunity. Differing from all commercial vitamin healthcare foods would cause some adverse effects due...
US-1,015,0971 Polynucleotide sequences and proteins encoded thereby useful for modifying plant characteristics
The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides. The present invention further relates to the uses...
US-1,015,0970 Methods to increase antigenicity of membrane-bound polypeptides produced in plants
Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds...
US-1,015,0969 Methods and compositions to regulate plant transformation susceptibility
A genetic screen for Arabidopsis mutants displaying a hyper-susceptible to Agrobacterium transformation (hat) phenotype was performed. The gene disrupted in the...
US-1,015,0968 Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in...
Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of...
US-1,015,0967 MicroRNA compounds and methods for modulating miR-122
Described herein are compositions and methods for the inhibition of miR-122 activity. The compositions have certain nucleoside modifications that yield potent...
US-1,015,0966 RNA sequence having anti-tumour activity
Provided is a novel useful microRNA having improved anti-tumor activity, obtained by introducing a variation in a microRNA which is present in-vivo and which...
US-1,015,0965 Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA
This invention relates to compounds, compositions, and methods useful for reducing transthyretin (TTR) target RNA and protein levels via use of dsRNAs, e.g.,...
US-1,015,0964 Partitioning and processing of analytes and other species
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a...
US-1,015,0963 Partitioning and processing of analytes and other species
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a...
US-1,015,0962 Methods for the selection of binding proteins
This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines...
US-1,015,0961 Methods for preparing monoclonal antibodies recognizing glycan binding site as an epitope
The present disclosure relates to a method for producing a monoclonal antibody that binds to an epitope for the glycan binding site of a glycoprotein. According...
US-1,015,0960 C-probe libraries for DNA target enrichment
Provided herein is a method for enriching a target nucleic acid molecule. In one embodiment, the method may involve hybridizing a C-probe to a strand of a...
US-1,015,0959 Immobilized ketoreductases and process for making and using immobilized ketoreductase
The invention is directed to immobilized ketoreductases and methods of making and using them. Enzymes are protein molecules which serve to accelerate the...
US-1,015,0958 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof,...
US-1,015,0957 Protease variants and polynucleotides encoding same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
US-1,015,0956 Compositions and methods comprising sequences having meganuclease activity
Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs,...
US-1,015,0955 Stabilized reverse transcriptase fusion proteins
Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the...
US-1,015,0954 Modified polymerases for improved incorporation of nucleotide analogues
Presented herein are polymerase enzymes for improved incorporation of nucleotide analogs, in particular nucleotides which are modified at the 3' sugar hydroxyl,...
US-1,015,0953 Well-tolerated and highly specific tailored recombinase for recombining asymmetric target sites in a plurality...
The present invention relates to a method for preparing an expression vector encoding a well-tolerated and highly specific tailored recombinase, which tailored...
US-1,015,0952 Compositions and methods for protein glycosylation
Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such...
US-1,015,0951 Process for producing N-propanol and propionic acid using metabolically engineered propionibacteria
A method is provided for making a banana or plantain product comprising providing at least one unpeeled banana or plantain comprising banana or plantain peel...
US-1,015,0950 Method for culturing mesenchymal stem cells according to cell size
A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 .mu.m or less and culturing the...
US-1,015,0949 Cardiomyocyte marker
The present invention provides a method for producing or detecting cardiomyocytes by extracting/detecting cardiomyocytes from a cell population which includes...
US-1,015,0948 Compositions and methods for producing and administering brown adipocytes
The present disclosure provides compositions comprising a hydrogel and a cell adhesion ligand that enhances the differentiation of mesenchymal stem cells into...
US-1,015,0947 Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect,...
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