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Patent # Description
US-1,015,0790 Depolymerisation of lignin in biomass
A method of obtaining depolymerized lignin from biomass using a transition metal catalyst and a solvent mixture of organic solvent and water. The invention...
US-1,015,0789 Molybdenum imide compound
In the method of the present invention for producing a thin film, including introducing, onto a substrate, a vapor that has been obtained by vaporizing a...
US-1,015,0788 Prodrug compounds and uses thereof
Provided herein are cyclic phosphorus-containing prodrug compounds, their preparation and their uses, such as treating diseases via modulating molecular targets...
US-1,015,0786 Silicone surfactants for emulsion assays
System, including methods and compositions, for making and using emulsions that include a silicone oil and a silicone surfactant. The emulsions may include...
US-1,015,0785 Method for producing dialkylaminosilane
In a method for synthesizing dialkylaminosilane from a reaction of dialkylamine with chlorosilane as the method for producing dialkylaminosilane, a large amount...
US-1,015,0784 Crystal polymorph of magnesium glycinate dihydrate and process for its preparation
Embodiments of the invention provide solid forms of magnesium glycinate dihydrate and compositions thereof, which are useful for treating hyperphosphatemia and...
US-1,015,0783 Heterocyclic ITK inhibitors for treating inflammation and cancer
Disclosed herein are heterocyclic compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of...
US-1,015,0782 Heterocycle-substituted bicyclic azole pesticides
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q is ##STR00002## and...
US-1,015,0781 2-oxothiatole compounds having activity as CPLA2 inhibitors for the treatment of inflammatory disorders and...
A compound of formula (I') ##STR00001## wherein R.sub.6 is H, C.sub.1-6alkyl, --(CH.sub.2).sub.pCOOH, --(CH.sub.2).sub.pCOOC.sub.1-6alkyl,...
US-1,015,0780 Spirocyclic heterocycle compounds useful as HIV integrase inhibitors
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, R.sup.1,...
US-1,015,0779 Aldose reductase inhibitors and methods of use thereof
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of...
US-1,015,0778 Production method of thienopyrimidine derivative
The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH)...
US-1,015,0777 Production of pyripyropenes from dry biomass
The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well...
US-1,015,0776 Harringtonines salts in the crystalline state and their use for the purification of the corresponding drug...
The present disclosure concerns harringtonines salts at the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and having general...
US-1,015,0775 6-amido derivatives of 4,5A-epoxymorphinans for treatment of pain
Compounds of formula: ##STR00001## in which R.sup.4 is chosen from substituted phenyl, optionally substituted naphthylene, optionally substituted anthracene...
US-1,015,0774 Compounds and methods
The subject matter generally relates to compounds and methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the...
US-1,015,0773 N-substituted 8-[(2,6-difluorobenzyl)oxy]-2,6- dimethylimidazo[1,2-a]pyrazin-3-carboxamide derivatives as...
The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides of general formula (I) ##STR00001## to processes for their...
US-1,015,0772 Crystalline forms of PARP inhibitors
The present disclosure relates to crystalline forms of 4,5,6,7-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1H-cyclo- ...
US-1,015,0771 Triazolopyrazinones as PDE1 inhibitors
The present invention provides triazolopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
US-1,015,0770 Crystal form of bisulfate of JAK inhibitor and preparation method therefor
A crystal form I of a Janus Kinase (JAK) inhibitor (3aR,5s,6aS)--N-(3-methoxyl-1,2,4-thiadiazole-5-yl)-5-(methyl(7H-pyrrolo[- ...
US-1,015,0769 Spiro-lactam NMDA modulators and methods of using same
Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression...
US-1,015,0768 Guanidine substituted imidazo[4,5-c] ring compounds
Imidazo[4,5-c] ring compounds, (particularly imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and...
US-1,015,0767 Therapeutic compounds and uses thereof
The present invention relates to compounds of formula (I): ##STR00001## and to salts thereof, wherein R.sup.1, R.sup.2, and Q have any of the values defined in...
US-1,015,0766 P2X7 modulators
The present invention is directed to compounds of Formula (I), which includes enantiomer and diasteromers thereof: ##STR00001## The invention also relates to...
US-1,015,0765 P2X7 modulators
The present invention is directed to compounds of Formulas (I, IIa and IIb): ##STR00001## The invention also relates to pharmaceutical compositions comprising...
US-1,015,0764 Substituted benzene compounds
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and...
US-1,015,0763 Histone deacetylase inhibitors and their use in therapy
A compound of the formula:(I) or a pharmaceutically acceptable salt thereof, wherein: L is a 5-membered nitrogen-containing heteroaryl which is optionally fused...
US-1,015,0762 Trifluoromethyl alcohols as modulators of ROR.gamma.t
The present invention comprises methods of making 5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-- ...
US-1,015,0761 Substituted pyridine-piperazinyl analogues as RSV antiviral compounds
The invention concerns novel substituted pyridine-piperazinyl analogs of formula (I) having antiviral activity, in particular, having an inhibitory activity on...
US-1,015,0760 Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor
Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small...
US-1,015,0759 1,4-pyridone bicycic heteroaryl compounds
The present invention relates to 1,4-pyridone bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these...
US-1,015,0758 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-1,015,0757 Quinazolinone derivatives as PARP inhibitors
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of...
US-1,015,0756 Diaminopyrimidine benzenesulfone derivatives and uses thereof
The present invention provides compounds of Formula (II) (e.g., compounds of Formula (I)), and pharmaceutically compositions thereof. Compounds of Formula (II)...
US-1,015,0755 ASK1 inhibitor compounds and uses thereof
Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds,...
US-1,015,0754 Histone demethylase inhibitors
The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject...
US-1,015,0753 Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyrdin-2-yl)acetamido- )...
Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamid- ...
US-1,015,0752 Substituted triazole derivatives as oxytocin antagonists
The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said...
US-1,015,0751 Pyrrolidine orexin receptor antagonists
The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
US-1,015,0750 Process for the oxidation of organic carbonyl compounds
A process for the oxidation of an organic carbonyl compound comprising reacting the compound, optionally in the presence of a solvent, with hydrogen peroxide in...
US-1,015,0749 Method for obtaining vitamin E, sterols and/or terpenes from oily or fatty mixtures of biological origin
Disclosed is a continuous process for concentrating or separating of vitamin E, sterols and/or terpenes from oily or fatty mixtures of biological origin...
US-1,015,0748 Salt or abexinostat, associated crystalline form, a process for their preparation and pharmaceutical...
Abexinostat tosylate of formula (II): ##STR00001## and its crystalline form I characterized by its X-ray powder diffraction diagram, its Raman spectrum and...
US-1,015,0747 Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
US-1,015,0746 Preparation of pantolactone
The present invention relates to a novel process for the preparation of pantolactone by reaction of hydroxypivalaldehyde cyanohydrin in a phase separation process.
US-1,015,0745 Process for the preparation of clobazam and its intermediate
The present invention provides an improved process for the preparation of 8-chloro-1-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (hereafter referred to as...
US-1,015,0744 P2X4 receptor antagonist
The present invention relates to a compound represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula,...
US-1,015,0743 Carboxylic acid compounds
The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: ##STR00001## wherein...
US-1,015,0742 Substituted heterocyclic compounds for treating or preventing viral infections
Disclosed herein are pyrimidine compounds of formula I and formula II and methods for treating or preventing a viral infection, such as infections caused by...
US-1,015,0741 Method for preparing azoxystrobin intermediates
The present invention provides a method for preparing azoxystrobin intermediates, comprising reacting compound A and dichloropyrimidine in the presence of a...
US-1,015,0740 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1 to R.sup.6 are as described herein, compositions including the...
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