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Patent # Description
US-1,016,7330 Modified recombinant variable lymphocyte receptors (VLR)
This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that...
US-1,016,7329 Stabilized insulin-like growth factor polypeptides
This invention is in the field of IGF-1 modifications. In particular, it relates to modified IGF-polypeptides and modified IGF-1 precursor polypeptides wherein...
US-1,016,7328 Methods for cancer therapy using mutant light molecules with increased affinity to receptors
Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These...
US-1,016,7326 Alpha-fetoprotein "ring and tail" peptides
The invention relates to compounds that are analogs of a cyclic peptide, cyclo[EKTOVNOGN], AFPep, that has anti-estrotrophic activity. The analogs of the...
US-1,016,7325 Plant-derived elastin binding protein ligands and methods of using the same
The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and...
US-1,016,7324 Pesticidal genes and methods of use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
US-1,016,7323 Nucleic acid molecules encoding insecticidal proteins
Improved compositions and methods for controlling pests are disclosed. In particular, nucleic acid molecules encoding novel engineered Cry1Ba (eCry1Ba) proteins...
US-1,016,7322 Engineered albumin binding polypeptide
The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to...
US-1,016,7321 Cytomegalovirus antigens and uses thereof
This disclosure provides modified cytomegalovirus (CMV) gL proteins and complexes comprising gL proteins. The modified gL proteins remain intact and are able to...
US-1,016,7320 Purification of virus like particles
Methods of purifying virus-like particles (VLPs) that are substantially free of process contaminants and infectious agents. The methods incorporate, for...
US-1,016,7319 Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications
The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various...
US-1,016,7318 D-enantiomeric peptides derived from D3 and use thereof
The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
US-1,016,7317 Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-1,016,7316 Anti-cancer peptide and use thereof
Provided are a peptide consisting of the amino acid sequence of SEQ ID NO:1 or a pharmaceutically acceptable salt thereof, and the use thereof. Cancer can be...
US-1,016,7315 Peptoids and methods for treating Alzheimer's disease
Provided herein are peptoids capable of inhibiting or reversing amyloid .beta. (A.beta.) fibril or plaque production. The peptoids form a helical structure with...
US-1,016,7314 Methods of treating depression and other related diseases
The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
US-1,016,7313 Selective caspase inhibitors and uses thereof
The present invention relates to compounds of Formula I, IA, II, IIA, III, or IIIA and their pharmaceutical uses. Particular aspects of the invention relate to...
US-1,016,7312 Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
A method of treating a disorder in a subject. The method comprises administering to said subject an effective amount of an agonist of the melanocortin-4...
US-1,016,7311 Boronic acid esters and pharmaceutical formulations thereof
Provided herein are boronic acid esters of boronic acid therapeutic agents, such as bortezomib. The boronic acid esters can be used to prepare liposomal...
US-1,016,7310 System and method for producing interleukin receptor antagonist (IRA)
The present invention relates to a system and method for producing high levels of autologous IL-1RA cytokine, comprising: a blood collection vessel (1), a cover...
US-1,016,7309 Asymmetric auxiliary group
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G.sup.1 and G.sup.2 are independently...
US-1,016,7308 Highly efficient synthesis of long RNA using reverse direction approach
The present invention relates to novel process of reverse 5'.fwdarw.3' directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has...
US-1,016,7307 Process for extraction of saponins from agricultural products
A process for the extraction and concentration of saponins from agricultural feedstocks. An agricultural feedstock can undergo a first preparation step intended...
US-1,016,7306 Crystalline form of 1-(beta-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]- benzene and...
The present invention relates to a crystalline form of 1-(.beta.-d-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethy- l]benzene. Specifically, it...
US-1,016,7305 Allyl complexes for use in coupling reactions
A complex of formula (1), ##STR00001## wherein, M is palladium or nickel, R.sub.1 and R.sub.2 are independently organic groups having 1-20 carbon atoms, or...
US-1,016,7304 Ruthenium compound, material for thin film formation, and process for thin film formation
Disclosed is a ruthenium compound useful as a precursor in chemical vapor growth, particularly ALD. The compound has good reactivity with a reactive gas, a high...
US-1,016,7303 Iridium organometallic complex containing a substituted dibenzo[f,h]quinoxaline and an electronic device having...
Iridium organometallic complexes containing a substituted dibenzo[f,h]quinoxaline having the formula ##STR00001## are provided. These compounds are useful as...
US-1,016,7302 Phosphonate nucleosides useful in the treatment of viral diseases
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, and their use in medicine particular as...
US-1,016,7301 Process for the preparation of bis(chloromethyl)dichlorosilane and bis(chloromethyl)(aryl)chlorosilane
The instant invention provides a process for the preparation of bis(chloromethyl)dichlorosilane (BCMCS) or bis(chloromethyl) (aryl)chlorosilane (BCMACS)...
US-1,016,7300 Metalloenzyme inhibitor compounds as fungicides
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof...
US-1,016,7299 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical...
Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by frmula (I), pharmaceutically acceptable salts, enantiomers,...
US-1,016,7298 Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof
The present invention relates to novel Pseudopolymorphs of Compound A, compositions comprising at least one Pseudopolymorph of Compound A, and methods of using...
US-1,016,7297 Substituted pyridine compounds having herbicidal activity
The present invention provides a substituted pyridine compound of the formula I ##STR00001## or an agriculturally suitable salt or N-oxide thereof, wherein...
US-1,016,7296 Sulfoximine substituted quinazolines for pharmaceutical compositions
The application relates to novel sulfoximine substituted quinazoline derivatives of formula ##STR00001## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are as...
US-1,016,7295 Analgesic compounds and methods of use
Provided herein, inter alia, are methods and compositions for achieving an analgesic effect in subjects in need thereof.
US-1,016,7294 Fused bicyclic compounds for the treatment of disease
Described herein are fused bicyclic compounds, compositions, and methods for their use for the treatment of disease.
US-1,016,7293 [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl- )methanones
The present invention covers [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-y- l)methanone compounds of general formula (I): ...
US-1,016,7292 Benzodiazepines as bromodomain inhibitors
The present invention provides novel benzodiazepine derivatives of Formula I or pharmaceutically acceptable derivatives, polymorphs, salts or prodrugs thereof....
US-1,016,7291 Pharmaceutical composition comprising a crystal form of (S)-4-(8-amino-3-(1-(but-2-ynoyl) ...
In some embodiments, the invention relates to crystalline solid forms, including hydrates, polymorphs, and salt forms, of ...
US-1,016,7290 Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Provided herein are methods for the preparation of substituted pyrazino[2,3-b]pyrazines of the formula (II): ##STR00001## the method comprising contacting a...
US-1,016,7289 Pyrazolopyrimidine compounds
The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also...
US-1,016,7288 Substituted pyrazolylpyrazole derivative and use of same as herbicide
Provided is a compound capable of effectively control worst weeds of higher leaf stages that present practical problems. A specific pyrazolylpyrazole derivative...
US-1,016,7287 Substituted pyrimidine compounds and methods of use and manufacture
This invention provides substituted pyrimidine compounds having the formula: ##STR00001## wherein X is absent, CH.sub.2, S, or O, and R is an alkyl group...
US-1,016,7286 Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
The disclosure is directed to compounds and pharmaceutically acceptable salts thereof for the treatment and/or prevention of neurodegenerative and/or...
US-1,016,7285 Small-molecule HSP90 inhibitors
Hsp90 inhibitors havin are provided havin the formula: (I) with a 2',4',5'-substitution pattern on the right-side aryl moiety. X1 represents two substituents,...
US-1,016,7284 Spirocyclic compounds as agonists of the muscarinic M.sub.1 receptor and/or M.sub.4 receptor
This invention relates to compounds that are agonists of the muscarinic M.sub.1 and/or M.sub.4 receptor and which are useful in the treatment of muscarinic...
US-1,016,7283 .beta.-lactamase inhibitors and uses thereof
The present invention relates to a compound of Formula (I)-(IV) useful as .beta.-lactamase inhibitor, a pharmaceutically acceptable salt, ester, solvate or...
US-1,016,7282 1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido [2, 3-B]pyrazin- 8-yl)oxy]phenyl]urea...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
US-1,016,7281 Substituted thiazole or oxazole P2X7 receptor antagonists
The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: ...
US-1,016,7280 Substituted oxopyridine derivatives
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments...
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