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Patent # Description
US-1,016,7279 Compounds and compositions as RAF kinase inhibitors
The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment...
US-1,016,7278 Cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator
The present invention relates to new cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator proteins, pharmaceutical...
US-1,016,7277 Activators of class I histone deacetlyases (HDACs) and uses thereof
The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals,...
US-1,016,7276 Compounds and methods for inhibiting JAK
Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a...
US-1,016,7275 AZD9291 intermediate and preparation method therefor
Disclosed are an intermediate, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-formamidine]phenyl- -2-propenamide (II), applicable in preparing AZD9291...
US-1,016,7273 Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof ##STR00001## in which q, R.sup.11, R.sup.12, R.sup.13...
US-1,016,7272 Muscarinic agonists
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and/or M.sub.4 receptor and which are useful in the treatment of...
US-1,016,7271 Fluoroquinolone carboxylic acid compounds and use thereof for the preparation of besifloxacin hydrochloride
The present invention relates to novel fluoroquinolone carboxylic acid compounds and derivatives of Formula-I, and their salts wherein, R represents H or...
US-1,016,7270 Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also...
US-1,016,7269 Cockroach attraction-aggregation substance, cockroach aggregation attractant and cockroach controlling agent
Provided is a solution for the problems associated with cockroach aggregation pheromones and cockroach aggregation attractants or cockroach controlling agents...
US-1,016,7268 Process for purifying a crude composition of dialkyl ester of 2,5-furandicarboxylic acid
An ester composition including at least 90% wt of the dialkyi ester of 2,5-furandicarboxylic acid as starting dialkyi ester concentration and up to 5% wt of the...
US-1,016,7267 Conversion and purification of biomass
The present invention relates to a method for synthesizing an optionally substituted furoic acid by dehydrating a biomass and oxidizing the optionally...
US-1,016,7266 Sodium channel blockers
The present invention relates to compounds of Formula (I) and pharmaceutical compositions thereof. Compounds of Formula (I) are epithelial sodium channel (ENaC)...
US-1,016,7265 Treatment of pulmonary and other conditions
Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X.sup.1-L-X.sup.2 wherein L is a linking moiety...
US-1,016,7264 Substituted pyrimidines useful as EGFR-T790M kinase inhibitors
The present invention is directed to novel pyrimidines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and...
US-1,016,7263 Treatment of amyotrophic lateral sclerosis
The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral...
US-1,016,7262 Herbicidal substituted 3-arylpyrazoles
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein X.sup.1, X.sup.2, X.sup.3, G and Q are as...
US-1,016,7261 2-oxo-3,4-dihydroquinolin-6-yl sulphonamide CPDS and their use as plant growth regulators
The present invention relates to sulfonamide derivatives of formula (I) where the substituents R1-R6 and R8, L, A and n are as defined in the application, to...
US-1,016,7260 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
US-1,016,7259 Allosteric inhibitors of proteasome and methods of use thereof
The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions...
US-1,016,7258 Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof
The present disclosure relates to the identification of PDK inhibitors and their use in the treatment of diseases such as diabetes, cardiovascular disease and...
US-1,016,7257 Indole derivatives for use in medicine
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the...
US-1,016,7256 Psychotrophic agents and uses thereof
Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition...
US-1,016,7255 Process for preparing amines
The present invention refers to a process for preparing amines comprising reacting a compound of the formula R.sup.1--CO--R.sup.2 comprising a carbonyl moiety...
US-1,016,7254 IDO inhibitors
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said...
US-1,016,7253 Ionizable compounds and compositions and uses thereof
This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle...
US-1,016,7252 Compounds and mixtures with antidegradant and antifatigue efficacy and compositions including such compounds
Antidegradant compounds are disclosed, and methods of making them, that are represented by the formula I: ##STR00001## wherein each X is independently...
US-1,016,7251 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial...
US-1,016,7250 Process for the preparation of 2-(trihalomethyl) benzamide
The present invention relates to a process for preparation of 2-(trihalomethyl) benzamide.
US-1,016,7249 Amino and imino propionic acids, process of preparation and use
N-alkyl, N-alkenyl, N-cycloalkyl, N-aryl amino or imino propionic acids with an alkyl chain ranging from 6 to 18 carbons, or alkenyl chain from 8 to 30 carbons,...
US-1,016,7248 Process for the reductive amination and selective hydrogenation of substrates containing a selected halogen
Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed...
US-1,016,7247 Solid forms of treprostinil
There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same.
US-1,016,7246 Preparative method for carboxylic acids
A preparative method for carboxylic acids is disclosed in the present invention. The method is characterized in that: compounds (II) are reacted in the presence...
US-1,016,7245 Method for hydroformylating cyclooctadiene using ...
A catalytic method for hydroformylating cyclooctadiene substrate involving forming a reaction mixture that includes the cyclooctadiene and a precursor of or a...
US-1,016,7244 Method for hydroformylating cyclooctadiene using 2-(anthracen-9-yloxy)-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane
A catalytic method for hydroformylating a cyclooctadiene substrate involving forming a reaction mixture that includes the cyclooctadiene and a precursor of or a...
US-1,016,7243 Biomass conversion process to hydrocarbons
An improved process for the production of a higher hydrocarbon from solid biomass is provided. Solid biomass that has been digested and hydrodeoxygenated in a...
US-1,016,7242 Process for preparing a C3-C7 (hydro) fluoroalkene by dehydrohalogenation
The invention provides a process for preparing a C.sub.3-7 (hydro)fluoroalkene comprising dehydrohalogenating a C.sub.3-7 hydro(halo)fluoroalkane in the...
US-1,016,7241 Two-bed paraffin to olefin enhancement process
A process is presented for the purification of an olefins feed stream to a benzene alkylation unit. The process removes heavy aromatics in a two adsorbent unit...
US-1,016,7240 Method and apparatus for solubilizing humic acid granules
Improved methods and apparatus (10, 74) for the solubilization of initially solid humic acids include a large-volume mixing/agitation tank (12, 76) for water...
US-1,016,7239 Pelleted feather meal and soybean meal based organic fertilizer
A process for production of a pelleted feather meal and soybean meal based organic fertilizer includes combining feather meal and soybean meal to create a...
US-1,016,7238 Micronutrient compositions and systems and methods of using same
An agricultural spray may be produced by admixing citric acid and glutamic acid with a metal salt and a pesticide or other agricultural chemical containing...
US-1,016,7237 Process and a plant for oxidative biostabilization of citrus pulp
A process for oxidative biostabilization of citrus pulp, comprising the following steps: feeding an amount of fresh citrus pulp, mixing said amount of fresh...
US-1,016,7236 Method for providing an inorganic coating to ammonium nitrate-based particles
The invention relates to a method for providing an inorganic coating to ammonium nitrate (AN) based particles, in particular to ammonium nitrate-based particles...
US-1,016,7235 Joined body and method for producing the same
A joined body 20 includes a porous ceramic 22 made of porous ceramic, a metal member 24 made of a metal, and a joint 30 formed of an oxide ceramic that...
US-1,016,7234 Method of making an alumina-silicate oxynitride and cubic boron nitride ceramic composite
A method for producing a composite of cubic boron nitride dispersed in a SiAlON ceramic. This method involves mixing silicon nitride nanoparticles, aluminum...
US-1,016,7233 Product having a high alumina content
A sintered refractory product having the form of a block and consisting of a granulate formed by all the grains having a size larger than 100 .mu.m, referred to...
US-1,016,7232 Process for making an ultra stable cementitious construction material
A process to make a cementitious material includes blending 29 wt % to 40 wt % of a magnesium oxide dry powder containing 80 wt % to 98 wt % of magnesium oxide...
US-1,016,7231 Process for making ultra stable tile backer board
A process to make a tile backer board includes using a stabilizing material with a phosphorus-containing compound, reacting magnesium containing starting...
US-1,016,7229 Quick-drying building material composition based on a mineral hybrid binder
A quick-drying gypsum composition, in particular for use as gypsum filling compound and for the production of floor coverings, wherein the gypsum composition...
US-1,016,7228 Lithium infused raw fly ash for the production of high strength cementitious products
A method of producing high-strength cementitious product from raw fly ash by mixing the raw fly ash with a lithium compound, whereby milling of the raw fly ash...
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