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Patent # Description
US-1,020,2640 Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
Methods and oligonucleotide reagents for analyzing individual T cells are disclosed. In particular, the present disclosure provides methods for analyzing...
US-1,020,2639 Development of novel detergents for use in PCR systems
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain...
US-1,020,2638 Compositions and methods for performing hybridizations with separate denaturation of the sample and probe
The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example,...
US-1,020,2637 Methods for analyzing nucleic acid
The invention generally relates to methods for analyzing nucleic acids. In certain aspects, methods of the invention involve obtaining a sample including a...
US-1,020,2636 Electrospun fibers for protein stabilization and storage
An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the...
US-1,020,2635 SRM/MRM assay for the ephrin type-A receptor 2 protein
Specific peptides, and derived ionization characteristics of the peptides, from the Ephrin Type-A Receptor 2 (EPHA2) protein are provided that are particularly...
US-1,020,2634 Detection of starch levels in biological matrices
Methods for detecting a starch in a sample are provided. The methods include the steps of initially incubating the sample in the presence of an...
US-1,020,2633 Polypeptide substrate for the detection of von Williebrand factor cleaving protease ADAMTS13
In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13...
US-1,020,2632 Enzymatic determination of HbA1c
A method for determining the amount of glycated hemoglobin (HbA1c), in which--if required--the erythrocytes in a sample are hemolyzed, the haemoglobin that is...
US-1,020,2631 Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for...
A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The...
US-1,020,2630 Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins,...
US-1,020,2629 Methods for amplification of nucleic acids utilizing clamp oligonucleotides
The present invention provides methods of amplifying a target nucleic acid utilizing a clamp oligonucleotide comprising a first target-binding region on the...
US-1,020,2628 Assembly of nucleic acid sequences in emulsions
Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided.
US-1,020,2627 Method for producing trehangelin
An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential...
US-1,020,2626 Compositions and methods for producing benzylisoquinoline alkaloids
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates...
US-1,020,2625 Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
Host cells that are engineered to produce benzylisoquinoline alkaloid (BIAs) precursors, such as norcoclaurine (NC) and norlaudanosoline (NL), are provided. The...
US-1,020,2624 Biosynthetic pathways and products
This disclosure describes biosynthesized compounds including anhydromevalonolactone and .beta.-methyl-.delta.-valerolactone. This disclosure further describes...
US-1,020,2623 Recombinant cell, and method for producing 1,4-butanediol
An object of the present invention is to provide a series of techniques for producing 1,4-butanediol from methanol or the like. Provided is a recombinant cell...
US-1,020,2622 Process for producing fuel using two fermentations
A process is provided for forming a fuel or a fuel intermediate from two fermentations that includes feeding an aqueous solution comprising a fermentation...
US-1,020,2621 Processing biomass
Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful...
US-1,020,2620 Synthesis of olefinic alcohols via enzymatic terminal hydroxylation
In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated...
US-1,020,2619 Compositions and methods directed to CRISPR/Cas genomic engineering systems
The invention relates to engineered CRISPR/Cas9 systems for genomic modification in mammalian cells. The present specification describes the design and testing...
US-1,020,2618 Method of treating type I diabetes using an AAV vector encoding uracortin 2
In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease,...
US-1,020,2617 Expression cassette for efficient surface display of antigenic proteins
An expression cassette, wherein said expression cassette comprises: (a) an ie 1 promoter from white spot syndrome virus or a variant thereof; (b) a nucleic acid...
US-1,020,2616 Promoter and regulatory elements for improved expression of heterologous genes in host cells
Disclosed are a recombinant expression vector and a host cell that contains the vector.
US-1,020,2615 Mammalian genes involved in toxicity and infection
The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more...
US-1,020,2614 Digestibility of plant biomass
Plants described herein have increased biomass and are more readily digested into fermentable sugars when the plants express increased levels of one or more...
US-1,020,2613 Methods for altering the reactivity of plant cell walls
Methods and means are provided to produce positively charged oligosaccharides in the plant cell wall by introducing into said plant cell a Nodulation C protein...
US-1,020,2612 Compositions, organisms, systems, and methods for expressing a gene product in plants
The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a...
US-1,020,2611 Vectors and methods for improved plant transformation efficiency
Methods and compositions for improved bacterial-mediated plant transformation are provided. The methods generally allow plant transformation with reduced vector...
US-1,020,2610 Recombinant K1-5 bacteriophages and uses thereof
The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5...
US-1,020,2609 Microorganisms producing L-amino acids and process for producing L-amino acids using the same
Disclosed are a recombinant microorganism having enhanced L-amino acid producibility, wherein the recombinant microorganism is transformed to have an...
US-1,020,2608 Iterative nucleic acid assembly using activation of vector-encoded traits
Certain aspects of the present invention provide methods for assembling nucleic acid molecules using iterative activation of one or more vector-encoded traits...
US-1,020,2607 Cleavable fusion tag for protein overexpression and purification
Provided are compositions and methods for enhancing recombinant protein production. The compositions and methods involve use of Ribose Binding Protein (RBP) as...
US-1,020,2606 Complex containing oligonucleotide having immunopotentiating activity and use thereof
The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly...
US-1,020,2605 Methods of identifying and treating poor-prognosis cancers
The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis...
US-1,020,2604 Methods of using microRNA-141
Provided herein are methods of treating a cancer in an individual. A microRNA-141 oligonucleotide or mimic that increases the expression of microRNA-141 in the...
US-1,020,2603 Modulation of huntingtin expression
Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and...
US-1,020,2602 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
Oligonucleotide analogs comprising modified intersubunit linkages and/or modified 3' and/or 5'-end groups are provided. The disclosed compounds are useful for...
US-1,020,2601 C/EBP.alpha. short activating RNA compositions and methods of use
The invention relates to saRNA targeting a C/EBP.alpha. transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic...
US-1,020,2600 AAV-based treatment of cholesterol-related disorders
The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention,...
US-1,020,2599 Selective antisense compounds and uses thereof
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but...
US-1,020,2598 Methods and systems for generation, use, and delivery of activated stem cells
Harvested stem cells are activated by treating them with an amplitude modulated laser beam having a wavelength lying in the range of 405 to 980 nanometers. The...
US-1,020,2597 Rapid cell purification systems
Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the...
US-1,020,2596 Porous membrane having immobilized enzyme, porous membrane composite including the same, and preparation method...
Disclosed herein is a porous membrane having an immobilized enzyme wherein the enzyme is immobilized within pores which are three-dimensionally connected to...
US-1,020,2595 Chimeric clotting factors
The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the...
US-1,020,2594 Proline-specific endoprotease and use thereof
The present invention relates to a polypeptide having proline-specific endoprotease activity, wherein the polypeptide has less than 70% residual activity when...
US-1,020,2593 Evolved sortases and uses thereof
Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind...
US-1,020,2592 Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
US-1,020,2591 Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders
The present disclosure provides for compositions comprising a chimeric polypeptide comprising a polypeptide effective for treating glycogen storage disease and...
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