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Patent # Description
US-1,020,2438 Synthetic library of specific binding molecules
The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure...
US-1,020,2437 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,020,2436 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,020,2435 Anti-PACAP antibodies and uses thereof
The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding...
US-1,020,2434 Fusion proteins of collagen-binding domain and parathyroid hormone
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a...
US-1,020,2433 IL-15 mutant polypeptides as IL-15 antagonists and encoding nucleic acids
The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In...
US-1,020,2432 Dual targeting drug carrier and application thereof
A dual targeting drug carrier is provided. The dual targeting drug carrier comprises a first targeting molecule and a second targeting molecule, wherein the...
US-1,020,2431 Stabilized P53 peptides and uses thereof
Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying...
US-1,020,2430 IgM-mediated receptor clustering and cell modulation
Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell,...
US-1,020,2429 Norrin regulation of cellular production of junction proteins and use to treat retinal vasculature edema
A method of tightening inter-cellular junctions in retinal or choroidal vessel cells includes exposing the retinal or choroidal vessel cells to norrin. Upon...
US-1,020,2428 Compositions and methods for the delivery of oxygen
H--NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H--NOX proteins...
US-1,020,2427 Esculentin-2CHa peptide and analogues thereof
The present invention relates to an esculentin-2CHa peptide and analogs thereof, and the use each thereof in the treatment of diabetes, for example type 2...
US-1,020,2426 Flagellin compositions and uses
The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.
US-1,020,2425 Selective recovery
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US-1,020,2424 Recombinant viral vectors
The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The...
US-1,020,2423 Picornavirus-like particle production in plants
A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic...
US-1,020,2422 Selective delivery molecules and methods of use
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
US-1,020,2421 Tumor-targeting compounds
The invention relates to a novel compounds targeting human cancer cells, a method for synthesis of such compounds, and use of such compounds in treating cancer.
US-1,020,2420 Methods and compositions for treatment of cartilage and disc tissue pathologies
An isolated polypeptide comprising a peptide selected from: i) DHX.sub.1SDNYT, wherein X.sub.1 is L or H (SEQ ID NO:3); ii) a conservative variant of i) iii) a...
US-1,020,2419 Connective tissue stimulating peptides
Novel peptides are described which comprise an amino acid motif selected from the group consisting of "PG", "GP", "PI" and "IG" and having up to 10 amino acids...
US-1,020,2418 Hydroxy-ethylene derivatives for the treatment of arthrosis
The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the...
US-1,020,2417 Purification method for vitamin K dependent proteins by anion exchange chromatography
The present invention relates to a method for the purification of Vitamin K dependent proteins with high yield and high purity, particularly enriched in active...
US-1,020,2416 Purification method for divalent cation binding proteins on anion exchange resin
The present invention relates to a method for the purification of divalent cation binding proteins with high purity on an anion exchange resin material, to...
US-1,020,2415 Method of synthesizing of 3-oxolupenal nanoparticles
A method for synthesizing 3-oxolupenal nanoparticles including isolating 3-oxolupenal from a fraction of Nuxia oppositifolia plant, reducing the 3-oxolupenal to...
US-1,020,2414 Process for preparing bile acid derivatives
The present invention relates to processes for preparing compounds of formula I or a pharmaceutically acceptable salt or solvate thereof, wherein the dashed...
US-1,020,2413 Neuroactive enantiomeric 15-, 16- and 17-substituted steroids as modulators for GABA type-A receptors
The present disclosure is generally directed to neuroactive enantiomeric 15-, 16- and 17-substituted steroids with additional optional substituents at carbons...
US-1,020,2412 .beta.-D-2'-deoxy-2'-substituted-4'-substituted-2-substituted-N.sup.6-subs- tituted-6-aminopurinenucleotides for...
A compound or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to a virus of the Paramyxoviridae...
US-1,020,2411 3'-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments,...
US-1,020,2410 Scaphopetalone analogs and their uses
The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.
US-1,020,2409 1, 1' -bis(phosphino)ferrocene ligands for alkoxycarbonylation
Compound of formula (I) ##STR00001## where R.sup.2, R.sup.4 are each independently selected from --(C.sub.1-C.sub.12)-alkyl, --(C.sub.3-C.sub.12)-cycloalkyl,...
US-1,020,2408 Prodrugs and methods of use thereof
The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are...
US-1,020,2407 Trisilyl amine derivative, method for preparing the same and silicon-containing thin film using the same
Provided are a novel trisilyl amine derivative, a method for preparing the same, and a silicon-containing thin film using the same, wherein the trisilyl amine...
US-1,020,2406 Boron cluster compounds and uses thereof
The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and...
US-1,020,2405 Fused pentacyclic imidazole derivatives
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or...
US-1,020,2404 Polycyclic pyridone derivative having integrase inhibitory activity
The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity,...
US-1,020,2403 Macrocyclic benzofuran compounds for the treatment of hepatitis C
Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
US-1,020,2402 Purification of rapamycin derivatives using temperature induced phase separation
The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also...
US-1,020,2401 Process for making tetracyclic heterocycle compounds
The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts...
US-1,020,2400 Cortistatin analogues and syntheses thereof
The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: ##STR00001## and salts thereof, wherein R.sub.1, R.sub.2,...
US-1,020,2399 Dihydroxy aromatic heterocyclic compound
Provided is a compound having a D-amino acid oxidase (DAAO) inhibitory action, and useful as, for example, a prophylaxis and/or therapeutic agent for...
US-1,020,2398 Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer
Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their...
US-1,020,2397 Anti-cancer compounds targeting Ral GTPases and methods of using the same
Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases...
US-1,020,2396 Process for improved opioid synthesis
Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an...
US-1,020,2395 Macrocycle with repeating triazole-carbazole units
Disclosed herein are compositions of tricarbazole triazolophane (tricarb) of Formulas (I), (II) and (III): ##STR00001## wherein R of Formula (I) is selected...
US-1,020,2394 Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
US-1,020,2393 Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-.alpha.]pyrrolo[2,3-e]-pyrazin-8-yl)-N-- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
US-1,020,2392 Synthesis of lactams
Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC--OR--NH-LG, wherein OR is an organic moiety and LG is a leaving...
US-1,020,2391 Chemical compounds
The present disclosure concerns compounds of Formula (I) ##STR00001## or pharmaceutically-acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.3 have...
US-1,020,2390 Heteroaryl substituted aminopyridine compounds
Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is a heteroaryl selected from imidazo[1,2-b]pyridazinyl and pyrazolo[1,5-a]pyrimidinyl,...
US-1,020,2389 Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: ##STR00001## or a pharmaceutically...
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