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Patent # Description
US-1,020,2388 Fused-ring compounds, pharmaceutical composition and uses thereof
This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising...
US-1,020,2387 Heterocyclyl linked imidazopyridazine derivatives as PI3KB inhibitors
The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) ##STR00001## wherein the variables have the meaning defined...
US-1,020,2386 Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon
Compounds of formula (I) and salts thereof: ##STR00001## wherein R.sup.1 is hydrogen, methyl or --(CH.sub.2).sub.2OR.sup.3, R.sup.2 is methyl or...
US-1,020,2385 Use of substituted 2,3-dihydroimidazo[1,2-C]quinazolines
The present invention relates to: --use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active...
US-1,020,2384 Solid forms of a toll-like receptor modulator
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropterid- in-6(5H)-one,...
US-1,020,2383 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted xanthines of general formula ##STR00001## wherein R.sup.1 to R.sup.3 are as defined herein, the tautomers, the...
US-1,020,2382 Azamorphinan derivatives and use thereof
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-1,020,2381 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
US-1,020,2380 Pesticidally active tetracyclic derivatives with sulfur containing substituents
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and...
US-1,020,2379 Substituted polycyclic carbamoyl pyridone derivative prodrug
The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of...
US-1,020,2378 Therapeutic compounds and uses thereof
The present invention relates to compounds of formula (I): ##STR00001## and to salts thereof, wherein R.sup.1-R.sup.6 have any of the values defined in the...
US-1,020,2377 3-(1H-benzo[D]imidazol-2-yl)-1H-pyrazolo[3,4-C]pyridine and therapeutic uses thereof
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
US-1,020,2375 N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors
Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In...
US-1,020,2374 6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors
The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R' are as herein described. The present invention particularly...
US-1,020,2373 Heteroaryls and uses thereof
The present invention provides a compound of formula I: ##STR00001## wherein R.sup.1, X.sup.1, X.sup.2, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n, and m are as...
US-1,020,2372 Trisubstituted pyrido[2,3-D]pyrimidines, methods for preparing same and therapeutic uses thereof
The present invention relates to compounds of the following general formula (I): ##STR00001## wherein: R.sub.1 is notably a group --NR.sub.aR.sub.b, R.sub.a...
US-1,020,2371 Oxazolidin-2-one-pyrimidine derivatives and the use thereof as phosphatidylinositol-3-kinase inhibitors
The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as...
US-1,020,2370 Benzimidazole derivatives as selective proteine kinase inhibitors
Disclosed are compounds of formula I or pharmaceutically acceptable salts thereof: ##STR00001## Wherein n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, A, Q...
US-1,020,2369 1,3-thiazol-2-yl substituted benzamides
The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical...
US-1,020,2368 CXCR7 receptor modulators
The present invention relates to derivatives of formula (I) ##STR00001## wherein (R.sup.1).sub.n, ring (A), Y.sup.1, Y.sup.2, X, R.sup.4, L.sup.1, L.sup.2,...
US-1,020,2367 Heterocyclic compounds and methods of use thereof
Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R.sup.1, A, and X are as defined in the specification. These compounds are...
US-1,020,2366 Methods of promoting wound healing using CRM1 inhibitors
The invention generally relates to the use of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural...
US-1,020,2365 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant...
US-1,020,2364 Forms and compositions of an ERK inhibitor
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
US-1,020,2363 Compounds, compositions and methods
The disclosed subject matter provides certain polymorphic forms of Compound (I) as well as pharmaceutical compositions comprising Compound (I) or such...
US-1,020,2362 Inhibitors of leukotriene A4 hydrolase
This present disclosure is directed to compounds of formula (I): ##STR00001## where R.sup.1a, R.sup.3, Y, and Z are described herein, as single stereoisomers...
US-1,020,2361 Pyridazinones as herbicides
Disclosed are compounds of Formula 1, including all stereoisomers, (N-oxides), and salts thereof, ##STR00001## wherein A, R.sup.1, R.sup.2 Q and J are as...
US-1,020,2360 Therapeutic compounds
The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said...
US-1,020,2358 Energy-efficient and environmentally friendly process for the production of target chemical compounds from...
The present invention is directed to an energy-efficient and environmentally friendly process for the production of chemical target compounds from cellulosic...
US-1,020,2357 Class of quinolone heterocyclic aromatic molecules for cancer treatment
The invention is directed to new class of quinolone heterocyclic aromatic molecules (Renotinibs) and their use in the treatment of cancer, in particular, cancer...
US-1,020,2356 JAK2 and ALK2 inhibitors and methods for their use
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): ##STR00001## including...
US-1,020,2355 Hydantoins that modulate bace-mediated app processing
In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular...
US-1,020,2354 Therapeutic compounds and uses thereof
The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically...
US-1,020,2353 Therapeutic compounds
Compounds of Formula I, or salts thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for...
US-1,020,2352 Process for preparation of aminopyrazole
The present disclosure relates to an improved diazotization process for the preparation of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl) pyrazole.
US-1,020,2351 Pyrazolyl derivatives as pest control agents
The invention comprises novel pyrazolyl derivatives of the general formula (I) ##STR00001## Also described are processes for preparing the compounds of the...
US-1,020,2350 MCT4 inhibitors for treating disease
Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the...
US-1,020,2349 Asymmetric bis-acridines with antitumour activity and their uses
We disclose novel asymmetric bis-acridines with antitumor activity. These compounds are useful for use in pharmaceuticals, particularly in the treatment or the...
US-1,020,2348 Compositions and methods of treating retinal disease
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin,...
US-1,020,2347 Compound, production method therefor, and use of said compound
The present application provides novel compounds having anti-cancer or anti-Helicobacter pylori activity, pharmaceutical compositions and method for producing...
US-1,020,2346 Phenol derivatives and the pharmaceutical or cosmetic use thereof
The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): ##STR00001## or one of its...
US-1,020,2345 Substituted azaspiro(4.5)decane derivatives
The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the .mu. opioid receptor and the ORL1 receptor, processes...
US-1,020,2344 Aryl substituted indoles and the use thereof
The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein...
US-1,020,2343 MIF modulators
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat...
US-1,020,2342 Targeted delivery of imaging probes for in vivo cellular imaging
The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in...
US-1,020,2341 Compositions comprising a reactive monomer and with a urea or urethane functional group
Disclosed herein are compositions comprising a reactive monomer, and, in particular, coating and/or reactive coating compositions. More particularly,...
US-1,020,2340 Glucosylceramide synthase inhibitors and therapeutic methods using the same
Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the...
US-1,020,2339 Therapeutic compounds and compositions
Provided are aryl sulfonamide diarylurea derivative compounds that are inhibitors of mutant isocitrate dehydrogenase 1/2 (IDH 1/2), useful for treating cancer....
US-1,020,2338 Topical compositions for the treatment of dermatological disorders
The present invention relates to pharmaceutical compositions and methods useful for the treatment of dermatological disorders, and in particular acne vulgaris...
US-1,020,2337 Method for producing tri-carbobenzoxy-arginine
A tri-carbobenzoxy-arginine represented by the following formula (2): ##STR00001## is produced by carbobenzoxylating the arginine or arginine derivative (1)...
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