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Patent # Description
US-1,025,8642 Dextran sulfate for use in mobilization of cells
Dextran sulfate in a range of 3500 and 9500 Da is employed to mobilize cells, such as stem and/or progenitor cells and certain white blood cells, in particular...
US-1,025,8641 Hydroxypropyl beta-cyclodextrin compositions and methods
This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally...
US-1,025,8640 Method of inhibiting quorum sensing in Pseudomonas aeruginosa
A method of inhibiting quorum sensing in Pseudomonas aeruginosa is provided. The method comprises contacting Pseudomonas aeruginosa with a gold(I) thiolate...
US-1,025,8639 Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy
Methods for treatment of insulin resistance and type II diabetes by administration of inhibitors of the PKI pathway are provided. In some aspects, inhibitors of...
US-1,025,8638 Administration of nicotinamide mononucleotide in the treatment of disease
Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases...
US-1,025,8637 Pharmaceutical composition, methods for treating and uses thereof
The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or...
US-1,025,8636 Prodrug salts
Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel...
US-1,025,8635 Formulations and compositions of vitamin D analogs for treating and preventing cancer and other diseases
This invention is for formulations of analogs of the non-toxic and inert Vitamin D3, its non-toxic and mostly inert pre-hormone and its toxic and biologically...
US-1,025,8634 Ciclesonide for the treatment of airway disease in horses
The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention relates to glucocorticoids, especially...
US-1,025,8633 Treatment of fibrosis using FXR ligands
The present invention relates to a method for inhibiting fibrosis that occurs in an organ where the farnesoid X receptor (FXR) is expressed. This method...
US-1,025,8632 Method of prevention of neurological diseases
Provided herein are small molecules that have a neuroprotective or modulatory effect in the nervous system. The small molecules provided herein modulate...
US-1,025,8631 Formulations of testosterone and methods of treatment therewith
The present disclosure relates to novel pharmaceutical composition for the administration of testosterone or testosterone derivatives. The present disclosure...
US-1,025,8630 Vaginal inserted estradiol pharmaceutical compositions and methods
In one aspect, compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises administering an...
US-1,025,8628 Generation of muscle lineage cells and therapeutic uses thereof
Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture...
US-1,025,8627 DNA-PK inhibitors
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
US-1,025,8626 Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): ##STR00001## wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Het are as defined in...
US-1,025,8625 Method for treatment of metastatic and refractory cancers and tumors with an inducer that overcomes inhibition...
A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor,...
US-1,025,8624 Modulators of cystic fibrosis transmembrane conductance regulator
The present invention features a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, where R.sub.1, R.sub.2, R.sub.3, W, X, Y,...
US-1,025,8623 Compositions and methods for reduction of amyloid-beta load
The present invention relates to methods and compositions for modulating levels of amyloid-.beta. peptide (A.beta.) exhibited by non-neuronal (i.e., peripheral)...
US-1,025,8622 Method of treating colorectal cancer by administration of pharmaceutical formulations of (S)-methyl ...
This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methyl-sulfonamido)phenyl)-1-isopropyl-1H- ...
US-1,025,8621 Methods and compositions for treating HIV-related disorders
Certain adjunctive therapies comprising a kynurenine-3-monooxygenase inhibitor and an antiviral agent for treating HIV-related disorders are provided herein....
US-1,025,8620 Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, pharmaceutical preparations...
The invention relates to the provision of a new crystalline form for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium, the use of this form for medical purposes,...
US-1,025,8619 Combination therapy with glutaminase inhibitors and immuno-oncology agents
The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase...
US-1,025,8618 Treating pulmonary conditions by selectively removing senescent cells from the lung using an intermittent...
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
US-1,025,8617 Dosing regimens for fast onset of antidepressant effect
A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition...
US-1,025,8616 Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and...
US-1,025,8615 Methods of treating a neurodegenerative disease in a mammal in need thereof
The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a...
US-1,025,8614 Compositions and methods for treating schizophrenia
The disclosure provides a novel polymorph of Compound (I): ##STR00001## 2-((1-(2-(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-o- ne...
US-1,025,8613 Compositions for treating retinal degeneration and methods of production and use thereof
Compositions for use in methods of treating and/or inhibiting a pathologic ocular condition, as well as methods of producing and using same, are disclosed.
US-1,025,8612 Mitochondrial lipid permeable iron chelators for treating and preventing ischemia/reperfusion (I/R) injury in...
Disclosed are methods and compositions for treating or preventing a disease or disorder responsive to a decrease in baseline mitochondrial iron in a subject in...
US-1,025,8611 Combination of ibudilast and riluzole and methods of using same
The present disclosure relates generally to methods for treating neurodegenerative diseases, including their progressive forms. In particular, the present...
US-1,025,8610 Pharmaceutical compositions comprising rifaximin, processes for their preparation and their use in the...
The invention relates generally to pharmaceutical compositions comprising rifaximin effective at treating vaginal infections, and in particular bacterial...
US-1,025,8609 Therapeutic agent for dyslipidemia
The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of...
US-1,025,8608 Formulations of deferasirox and methods of making the same
The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the...
US-1,025,8607 Method of increasing intratumoral pHe and reducing acid-mediated invasion
A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to...
US-1,025,8606 Endothelin single nucleotide polymorphisms and methods of predicting .beta.-adrenergic receptor targeting agent...
The present invention concerns the use of methods for evaluating .beta.-adrenergic receptor targeting agent treatment for a patient, particularly one with a...
US-1,025,8605 Use of indole compounds for fat reduction and skin and soft tissue tightening
The present invention relates to indole compounds and compositions and uses thereof, including uses of the indole compounds and compositions for the reduction...
US-1,025,8604 Lasofoxifene treatment of breast cancer
The disclosure provides methods for treating estrogen receptor positive (ER.sup.+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically...
US-1,025,8603 Therapeutic compounds and uses thereof
The present invention relates to compounds of formula (I): ##STR00001## and to salts thereof, wherein R.sup.1, R.sup.2, R.sup.c, and R.sup.d have any of the...
US-1,025,8602 Macrocyclic ghrelin receptor modulators and methods of using the same
The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth...
US-1,025,8601 Vaporizable cannabinoid compositions
A composition for producing a pharmacological effect is provided, which includes a bio-active ingredient and a carrier liquid solution. The bio-active...
US-1,025,8600 Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and...
US-1,025,8599 Compounds for use in the prevention or treatment of cancer
The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to...
US-1,025,8598 Compounds for use in the prevention or treatment of cancer
The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to...
US-1,025,8597 Method for treating a glycoprotein-related disease
A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective...
US-1,025,8596 Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer;...
US-1,025,8595 Pharmaceutical formulation for histone deacetylase inhibitors
A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following...
US-1,025,8594 Cat appeasing pheromone
Disclosed is a semiochemical composition including methyl palmitate, methyl linoleate, methyl oleate methyl stearate, methyl laurate, methyl myristate, salts...
US-1,025,8593 Semiochemical compositions to reduce social conflicts with cats
A semiochemical composition including methyl laurate, methyl myristate, methyl palmitate, methyl linoleate, methyl oleate, methyl stearate, dimethyl pimelate,...
US-1,025,8592 Compositions and methods of use of phorbol esters
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such...
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