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Patent # Description
US-1,025,9816 Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical...
Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications...
US-1,025,9815 Gabaergic ligands and their uses
Described herein are .alpha.3 or .alpha.2 or .alpha.2/.alpha.3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of...
US-1,025,9814 Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or...
US-1,025,9813 Compositions comprising folic acid derivatives, their preparations and methods of use
Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.
US-1,025,9812 CGRP receptor antagonists
The disclosures herein relate to novel compounds of formula ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, and their use in...
US-1,025,9811 Tank-binding kinase inhibitor compounds
Compounds having the following formula (I) and methods of their use and preparation are disclosed: ##STR00001##
US-1,025,9810 N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use
The present invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have any of the...
US-1,025,9809 Fluorinated imidazo[4,5-C]quinoline derivatives as inhibitors of bromodomain containing proteins
A novel class of fluorinated derivatives of Formula (I) have been prepared and found to be useful in the treatment of cancers and other disorders related...
US-1,025,9808 Aryl sultam derivatives as RORc modulators
Compounds of the formula I: ##STR00001## or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X.sup.1, X.sup.2, X.sup.3, X.sup.4, Y, Z, A,...
US-1,025,9807 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
The invention relates to compounds of Formula (I) ##STR00001## wherein X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as described in the...
US-1,025,9806 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2 pyridyl]amino]pyrazine-2-carbonitrile and therapeutic...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to ...
US-1,025,9805 Process for making crystalline form a of gefitinib
The present invention relates to a process for preparation of crystalline Form 1 of gefitinib of formula (1) characterized by a XRPD powder diffraction pattern...
US-1,025,9804 Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention of...
Endothelial Lipase (EL) inhibitors and methods of using such inhibitors for treating conditions implicating EL are provided herein. The present invention meets...
US-1,025,9803 Therapeutic inhibitory compounds
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma...
US-1,025,9802 Bicyclic aza compounds as muscarinic M1 receptor antagonists
This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1...
US-1,025,9801 Anti-inflammatory and antitumor 2-oxothiazoles ABD 2-oxothiophenes compounds
A compound of formula (I) ##STR00001## wherein X is O, C.dbd.O or S; Y is N or CH; R.sub.2 and R.sub.4 are each independently H, --(CH.sub.2).sub.pCOOH,...
US-1,025,9800 Method of fluorination using iodonium ylides
A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using .sup.18F is described. Processes,...
US-1,025,9799 Hydroxyl pyranone compound, method for producing same, and cosmetics composition comprising compound
The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl...
US-1,025,9798 High-purity magnesium lithospermate B and preparation method therefor
The present invention relates to a method for preparing magnesium lithospermate B. The method is characterized in that: magnesium lithospermate B is extracted...
US-1,025,9797 Process for preparing a mixture comprising 5-(hydroxymethyl) furfural and specific HMF esters
Provided herein is a process for preparing a mixture including 5-(hydroxy-methyl)furfural (HMF) and one or more HMF esters of formula (I), the process including...
US-1,025,9796 Oxaspiro[2.5]octane derivatives and analogs
The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and...
US-1,025,9795 Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
The invention provides .alpha.-amino esters of a hydroxypropylthiazolidine carboxamide derivative, ...
US-1,025,9794 Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives
The present disclosure is directed to improved methods useful for the preparation of, for example, ...
US-1,025,9792 Crystal of uracil compound
The present invention provides a crystal that has preferable oral absorption and can be obtained with particularly preferable reproducibility. Provided is a...
US-1,025,9791 High-purity quinoline derivative and method for manufacturing same
Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less....
US-1,025,9790 Polymorphic forms of pitavastatin sodium
The present invention is directed to polymorphic forms of Pitavastatin sodium and processes for preparation of the same.
US-1,025,9789 Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids
4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo...
US-1,025,9788 Ionic liquids comprising heteraromatic anions
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally...
US-1,025,9787 Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor or M.sub.1 and M.sub.4 receptors and which are useful in the treatment...
US-1,025,9786 Psychotropic agents and uses thereof
Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition...
US-1,025,9785 Therapeutic compounds and compositions
The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition.
US-1,025,9784 Method and catalyst for synthesising aziridine
The present invention relates to methods of synthesizing aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or...
US-1,025,9783 Carbondisulfide derived zwitterions
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be...
US-1,025,9782 ROR gamma (ROR.gamma.) modulators
Compounds according to Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof wherein: A.sub.1 is NR.sub.1 or CR.sub.1, with R.sub.1 being H or...
US-1,025,9781 Imaging agents
Provided herein is technology relating to imaging agents and particularly, but not exclusively, to methods of manufacturing fluorine-18-labeled...
US-1,025,9780 Treatment of cataplexy
The present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically...
US-1,025,9779 Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8...
A compound having formula I for histone deacetylase inhibition is provided: ##STR00001## or a pharmaceutically acceptable salt or hydrate thereof wherein R is...
US-1,025,9778 Process for the preparation of raltegravir
The present invention provides a process for the preparation of crystalline anhydrous compound of Formula (X), Further, the present invention relates to the use...
US-1,025,9777 (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide for treatment of neurodegenerative diseases
The present invention pertains to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ...
US-1,025,9776 Branched 3-phenylpropionic acid derivatives and their use
The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes...
US-1,025,9775 Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically...
US-1,025,9774 Antimicrobials for preservation of home and personal care products
Disclosed herein are antimicrobial N-Alkyl-N,N-bis(2-carboxyethyl)-N-benzyl ammonium chlorides of Formula I for preservation of home and personal care products....
US-1,025,9773 Curable composition for inkjet, and method for manufacturing electronic component
Provided is a curable composition for inkjet which can have a prolonged pot life even under an environment in an inkjet device that is warmed to 50.degree. C....
US-1,025,9772 Agents for maintaining undifferentiated state and promoting proliferation of stem cells
An object of the present invention is to find a novel substance that is capable of efficiently promoting the proliferation of stem cells while maintaining the...
US-1,025,9771 Vegetable oil polyol and the preparation method and the application thereof
A preparation method of vegetable oil polyol, which is obtains by carrying out allylic oxidation treatment of vegetable oil, increasing the content of hydroxyl...
US-1,025,9770 Process for the preparation of ethacrynic acid
The invention provides an improved process for preparing Ethacrynic acid of formula I, including the steps of: (a) reacting 4-butyryl-2,3-dichloro-phenoxy...
US-1,025,9769 Conversion of polystyrene to benzoic acid
Polystyrene-containing polymers are converted to benzoic acid by catalytic oxidation of dissolved polystyrene under elevated temperature and pressure. The...
US-1,025,9768 Method of recycling a polyester
A method of recycling a polyester includes the steps of providing the polyester, preparing a solution containing water and an alcohol, submerging the polyester...
US-1,025,9767 Method for the preparation of alkylsalicylaldehyde and alkylsalicylaldoxime, and use thereof
The invention relates to an improved method for the preparation of alkylsalicylaldehyde or its corresponding metallic salts. The invention also relates to a...
US-1,025,9766 Preparation method for 2,3-pentanedione
A preparation method for 2,3-pentanedione, including the steps of adding one or both of 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone into water and...
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