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Patent # Description
US-1,027,3286 Fibronectin based scaffold proteins having improved stability
The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of...
US-1,027,3285 Fusion proteins and uses thereof
The present disclosure relates to fusion proteins that are highly useful for the generation of virus-like particles for the display of membrane spanning...
US-1,027,3284 Cytokine-based fusion proteins for treatment of immune disorders
The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine....
US-1,027,3283 Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof
Described herein are modified integrin .alpha. and/or .beta. headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified...
US-1,027,3282 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,027,3281 CD80 extracellular domain polypeptides and their use in cancer treatment
This application relates to CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in treatment of cancer, both alone...
US-1,027,3280 Chimeric antigen receptors (CARs), targeting hematologic malignancies, compositions and methods of use thereof
The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens,...
US-1,027,3279 Protease activated receptor-1 (PAR1) derived cytoprotective polypeptides and related methods
The present invention provides novel PAR1 derived cytoprotective oligopeptides or polypeptides which typically contain at least the first 4 N-terminal residues...
US-1,027,3278 Epitope recognized by anti-interferon gamma autoantibodies in patients with disseminated mycobacterial...
The present invention discloses a fragment of peptide which can be utilized in patients suffering from a disseminated mycobacterial infection. The fragment of...
US-1,027,3277 Method for purifying PEGylated erythropoietin
Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or...
US-1,027,3276 Rspondins as modulators of angiogenesis and vasculogenesis
The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors...
US-1,027,3275 Muteins of human lipocalin 2 with affinity for glypican-3 (GPC3) and methods of use thereof
The present disclosure relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Glypican-3 (GPC3), which proteins preferably...
US-1,027,3274 Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the...
US-1,027,3273 Compositions for regulating iron homeostasis and methods of using same
The present invention relates to hemojuvelin-IgG Fc domain fusion proteins, variants, derivatives, fragments and peptide mimetics derived therefrom and methods...
US-1,027,3272 Antimicrobial peptides
The present invention provides novel antimicrobial peptides and nucleic acids encoding them, the peptides having an inhibitory or bactericidal/bacteriostatic...
US-1,027,3271 Methods of transcription activator like effector assembly
The disclosure describes methods that include providing a first nucleic acid having a sequence encoding a first set comprising one or more transcription...
US-1,027,3270 Protein capable of binding specifically to immunoglobulin, and immunoglobulin-binding affinity ligand
An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the acidic condition...
US-1,027,3269 High potency immunogenic zika virus compositions
Provided herein, in some embodiments, are Zika Virus immunogenic compositions that include a cationic lipid nanoparticle (LNP) encapsulating messenger...
US-1,027,3268 HIV vaccine formulation
Immunogenic compositions containing a human immunodeficiency virus (HIV) gp140 protein, sorbitol, polysorbate 20, and histidine buffer are described. The...
US-1,027,3267 Beta-hairpin peptidomimetics as selective elastase inhibitors
.beta.-Hairpin peptidomimetics of the general formula cyclo(-Xaa.sup.1-Xaa.sup.2-Thr.sup.3-Xaa.sup.4-Ser.sup.5-Xaa.sup.6-Xaa.su- ...
US-1,027,3266 Multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of...
The present invention relates to a multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of recombinant proteins,...
US-1,027,3265 Epitope tag and method for detection and/or purification of tagged polypeptides
Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of...
US-1,027,3264 Cortistatin analogues and syntheses and uses thereof
Compounds of Formula (A'), (B'), (C'), (D'), (E'), (A''), (B''), (C''), (D''), (E''), (G1), and (G2) are useful as therapeutics for treating a wide variety of...
US-1,027,3263 Pro-drug forming compounds
Various prodrug compounds having the general structure: Active agent--(acid)-(linker)--SO.sub.2NR.sub.1R.sub.2 are described herein. Compounds having this...
US-1,027,3262 Crystalline form A of obeticholic acid and preparation method thereof
The present invention relates to crystalline Form A of obeticholic acid and the preparation method thereof. The present invention provides Form A having...
US-1,027,3261 Design, synthesis and use of synthetic nucleotides comprising charge mass tags
Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge...
US-1,027,3260 Compounds and methods for treating bacterial infections
The present invention encompasses compounds and methods for treating urinary tract infections.
US-1,027,3259 Tricyclic sulfones as ROR.gamma. modulators
There are described ROR.gamma. modulators of the formula (I), ##STR00001## and formula (II) ##STR00002## or stereoisomers, tautomers, pharmaceutically...
US-1,027,3257 Cancer cell-containing composition
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
US-1,027,3256 Macrocycles
The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
US-1,027,3255 High-purity large-scale preparation of stannsoporfin
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
US-1,027,3254 Process for preparing an acryloyloxysilane
A process for preparing an acryloyloxysilane, comprising: reacting a metal salt of a carboxylic acid having the formula ...
US-1,027,3253 Method for producing an ionic liquid
The present invention is directed to a method of preparing an alkoxy silane functional ionic liquid comprising reacting a halogenated compound comprising a...
US-1,027,3252 Substituted dihydropyrrolopyrazole derivative
The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia),...
US-1,027,3251 Composition, cured film, near infrared ray absorption filter, solid-state imaging device, infrared sensor, and...
It is possible to provide a composition that has absorption in a near infrared region and that can form a film having transparency in a visible region. Provided...
US-1,027,3250 Use for boron formates for reducing unsaturated organic functions
The present invention relates to a method for reducing unsaturated organic compounds chosen from the group formed by the aldehydes, the ketones, the imines, the...
US-1,027,3249 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
US-1,027,3248 Glucose uptake inhibitors
Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases,...
US-1,027,3247 Imidazothiazole derivatives as modulators of TNF activity
A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are accordingly of...
US-1,027,3246 Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3',4':5,6] pyrazino[2,3-B] indole analogs as...
In one aspect, the invention relates to substituted 5H-[1,2,5]oxadiazolo [3',4':5,6]pyrazino[2,3-b]indole analogs, derivatives thereof, and related compound;...
US-1,027,3245 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The...
US-1,027,3244 Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators
The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine...
US-1,027,3243 4-phenylpiperidines, their preparation and use
The present invention provides a compound having the structure: (structurally represented) wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each...
US-1,027,3242 Compound inhibiting activities of BTK and/or JAK3 kinases
The present invention relates to a compound inhibiting the activities of Bruton's tyrosine kinase (BTK) and/or Janus kinase 3 (JAK3), a pharmaceutical...
US-1,027,3241 Cortistatin analogues and syntheses and uses thereof
Provided herein are compounds of Formula (A), (B), (C), (D) and (E), pharmaceutically acceptable salts, quaternary amine salts, and N-oxides thereof, and...
US-1,027,3240 Cortistatin analogues, syntheses, and uses thereof
New cortistatin compounds and pharmaceutically acceptable salts and pharmaceutically acceptable compositions thereof are provided. These compounds can be used...
US-1,027,3239 Spiro-lactam NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
US-1,027,3238 Indazolones as modulators of TNF signaling
The disclosure provides compounds of Formula (I) ##STR00001## pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and...
US-1,027,3237 Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN-.alpha. responses
Compounds having the following formula (I), or a stereoisomer or pharmaceutically-acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5...
US-1,027,3236 Macrocyclic factor XIa inhibitors bearing heterocyclic groups
The present invention provides compounds of Formula (Ia): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all...
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