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Patent # Description
US-1,027,3488 Nuclease-mediated DNA assembly
Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end...
US-1,027,3487 Transfection vector for pathogenic amoebae and uses thereof
Disclosed herein are expression vectors suitable for transfection in amoebas. The vectors may include a promoter from a protein-encoding gene from an amoeba, a...
US-1,027,3486 Method for modulating gene expression by modifying the CpG content
The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The...
US-1,027,3485 Modified microorganism with improved biomass separation behaviour
The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene....
US-1,027,3484 Double-stranded RNA conjugates and their use
Double-stranded ribonucleic acids (dsRNA) of at least 45 bp, preferably of at least 50 bp, which dsRNA include at least one 5'-triphosphate group and further...
US-1,027,3483 Compositions and methods for correcting limb girdle muscular dystrophy type 2C using exon skipping
The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the...
US-1,027,3482 dsRNA for treating viral infection
The invention relates to double-stranded ribonucleic acids (dsRNAs) targeting gene expression of phosphatidylinositol 4-kinase (PI4K), in particular human...
US-1,027,3481 SiRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia
Provided is an siRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia, and particularly, provided are a method of a tandem...
US-1,027,3480 MCP-1 binding nucleic acids
The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group comprising type 1A nucleic acids, type 1B nucleic...
US-1,027,3479 .beta.-actin promoters and uses thereof
The invention relates to isolation of novel .beta.-actin promoters and uses thereof. In particular, this invention features nucleotide sequences for rodent...
US-1,027,3478 Compositions and methods for inhibition of expression of protein C (PROC) genes
The invention relates to double-stranded ribonucleic acid (dsRNA) targeting a PROC gene, and methods of using the dsRNA to inhibit expression of PROC.
US-1,027,3477 Therapeutic compositions
This application relates to therapeutic siRNA agents and methods of making and using the agents.
US-1,027,3476 MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain...
US-1,027,3475 Regulation of BARD1 expression by non-coding RNA
The present invention relates to a long non-coding BARD1 RNA molecule named BARD1 9'L. The present invention also relates to siRNAs for therapeutic use, for...
US-1,027,3474 Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for...
US-1,027,3473 Method of normalizing biological samples
The present disclosure relates to normalization of biological samples, particularly samples comprising nucleic acids to be sequenced. The normalization...
US-1,027,3472 Methods of utilizing recombination for the identification of binding moieties
The identification of binding moieties capable of selectively interacting with one or more target antigens is of scientific, medical, and commercial value....
US-1,027,3471 Compositions and methods for multiplex nucleic acids synthesis
Aspects of the invention relate to methods, compositions for designing and producing a target nucleic acid. In particular, aspects of the invention relate to...
US-1,027,3470 Method for isolating RNA from a RNA and DNA containing sample
The present invention pertains to a method for isolating RNA, including small RNA from a RNA and DNA containing sample, wherein the sample is lysed and the...
US-1,027,3469 Probiotic bacteria comprising metals, metal nanoparticles and uses thereof
The invention relates to probiotic bacteria selected from lactic acid bacteria, such as Lactobacillus and Bifidobacteria, having metals and/or metal...
US-1,027,3468 Inhibition and diagnostics of emerging tetracycline resistance enzymes
The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that...
US-1,027,3467 Maltooligosyl trehalose synthase mutant and its application
The present invention relates to the field of genetic engineering and enzyme engineering, and more particularly relates to a maltooligosyl trehalose synthase...
US-1,027,3466 Short-acting factor VII polypeptides
Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the...
US-1,027,3465 Glycosyl hydrolase enzymes and uses thereof
The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and...
US-1,027,3464 Methods and isolated protein compositions for isoprenoid diphosphate synthesis
Provided herein are methods and compositions relating to the synthesis of isoprenoid diphosphates using a mutated isopentenyl phosphate kinase.
US-1,027,3463 Chemiluminescent wetness indicator for absorbent products
Disclosed herein are fluff pulp compositions, absorbent articles comprising the fluff pulp compositions, and related methods. The fluff pulp compositions...
US-1,027,3462 Virus-based vector compositions useful for transducing eukaryotic cells
The present invention provides viral vector compositions of high titer and purity, as well as methods for production of said compositions. The methods of the...
US-1,027,3461 Employing human adipose-derived stem cells to propagate serum-derived hepatitis C virus and use thereof
Hepatitis C virus replication at extrahepatic sites has been suggested; however, complete viral replication has only been confirmed in hepatocytes. Here we show...
US-1,027,3460 Recombinant phage for listeria detection
Methods of detecting target bacteria are provided. In some embodiments, the methods comprise exposing a sample to a phage capable of infecting target bacteria,...
US-1,027,3459 Automated system for producing induced pluripotent stem cells or differentiated cells
The invention provides an automated system for producing induced pluripotent stem cells (iPSCs) from adult somatic cells. Further, the system is used for...
US-1,027,3458 ZSCAN4 as a marker for pancreatic stem cells and progenitor cells and use thereof
ZSCAN4, a gene expressed in ES cells and 2-cell stage embryos, has been previously shown to regulate telomere elongation and genome stability in mouse ES cells....
US-1,027,3457 Method of obtaining a population of cells
A method of obtaining stromal progenitor cells (SPC) from subcutaneous adipose tissue by incubation of a very small volume of the subcutaneous adipose tissue in...
US-1,027,3456 Automated methods and systems for washing platelet concentrates
Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed...
US-1,027,3454 Means and methods for influencing the stability of antibody producing cells
The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6...
US-1,027,3453 Method for stem cell differentiation in vivo by delivery of morphogenes with mesoporous silica and...
A pharmaceutical active ingredient for cell differentiation to alleviate cell and cell-related deficiencies in mammals comprising porous silica containing a...
US-1,027,3452 Specification of functional cranial placode derivatives from human pluripotent stem cells
Cranial placodes are embryonic structures essential for sensory and endocrine organ development. The efficient derivation of cranial placodes from human...
US-1,027,3451 Immortalization of cells including neuronal cells
The instant invention provides methods for immortalizing cells. The invention further provides immortalized cell lines, e.g., neuronal cell lines, and methods...
US-1,027,3450 Isolated human lung progenitor cells and uses thereof
Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells...
US-1,027,3449 Induction medium and methods for stem cell culture and therapy
Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell...
US-1,027,3448 Medium containing uridine and N-acetyl-D-mannosamine
Provided are a novel medium for expressing glycoproteins by culturing cells and a method for producing glycoproteins by culturing cells in the medium. Further...
US-1,027,3447 Pentose-fermenting strain with optimized propagation
The present invention relates to a method for obtaining a strain capable of efficiently propagating in a low nutritive potential medium, capable of metabolizing...
US-1,027,3446 Compositions and methods for recovery of stranded gas and oil
The present disclosure provides compositions and methods for using recombinant C1 metabolizing microorganisms capable of metabolizing sulfur containing...
US-1,027,3445 Isolated strain of Clonostachys rosea for use as a biological control agent
Described is an isolated strain of the fungus Colonostachys rosea termed BVT Cr-7 useful as a biological control agent for the treatment of plants. The isolated...
US-1,027,3444 Lysis/resealing process and device for incorporating an active ingredient, in particular asparaginase or...
A lysis/resealing process for preparing erythrocytes containing active ingredient is provided comprising placing a globular concentrate in suspension in an...
US-1,027,3443 Microbial experiment cooling and temperature-sensing multipurpose rack
A multi-function cooling and thermo-sensitive rack includes horizontal bars, a base, positioning holes, connectors, a lateral frame, connecting holes, a...
US-1,027,3442 Device and method for concomitant ejection and suction of perfusate
A device and methodology for concomitant ejection and suction of a perfusate (CESOP) within a region of interest without spillover of the perfusate to a...
US-1,027,3441 Perfusion manifold assembly
The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device...
US-1,027,3440 Devices and methods for creating and testing microbes and biofilms
Systems and methods for growing microbes and biofilms on a hydrogel in a controlled environment. The system can have a cup, and a liner with the liner inserted...
US-1,027,3439 Alcoholic beverage concentrate process
Methods and systems for forming a concentrate from an alcoholic beverage, such as a beverage made by fermentation processes. A membrane process may be used to...
US-1,027,3438 Container comprising a detergent composition containing GLDA
Container comprising a single unit dose of a detergent composition containing at least one complexing agent (A) dissolved in an aqueous medium, said complexing...
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