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Patent # Description
US-1,028,0228 Treatment with anti-ErbB2 antibodies
The present invention concerns dosages for treatment of human cancer patients with an anti-Epidermal Growth Factor Receptor (EGFR) antibody.
US-1,028,0226 Anti-GITR antibodies and methods of use thereof
The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions...
US-1,028,0225 Compositions and methods for non-myeloablative conditioning
Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers, such as the CD34, CD45 or CD117 receptors,...
US-1,028,0224 Anti-PD-1 antibodies
Anti-PD-1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
US-1,028,0223 Anti-canine PD-1 antibody or anti-canine PD-L1 antibody
The object of the present invention is to provide an anti-canine PD-1 antibody or an anti-canine PD-L1 antibody, an agent for inhibiting binding between a...
US-1,028,0222 Humanized antibodies with increased stability
The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies...
US-1,028,0221 Anti-LAG-3 binding proteins
Antigen binding proteins that bind Lymphocyte Activation Gene 3 (LAG-3), and more particularly to antigen binding proteins that cause depletion of LAG-3+...
US-1,028,0220 Immunoconjugates with an intracellularly-cleavable linkage
The invention relates to therapeutic conjugates with improved ability to target various cancer cells containing a targeting moiety and a therapeutic moiety. The...
US-1,028,0219 Antibodies to M-CSF
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to...
US-1,028,0218 Antibodies binding to BMP4, and uses thereof
The present invention relates to antibody which binds to an epitope located within the BMPR1 binding region of BMP4.
US-1,028,0217 Cell culture additives and their use for increased bioprotein production from cells
The invention relates to a method of increasing protein biomolecule production in which a) a cell that produces a heterologous protein biomolecule is cultured,...
US-1,028,0216 Anti-malignant tumor agent
The present invention provides an antitumor agent having high safety, which is a molecular target drug against malignant tumors. An anti-malignant tumor agent...
US-1,028,0215 Anti-C5 antibodies and methods of treating complement-related diseases
The present invention relates to an antibody against C5, and a method for preventing and treating complement-related diseases using the antibody, wherein the...
US-1,028,0214 Glycosylated repeat-motif-molecule conjugates
Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule-linker.sub.n).sub.m-conjugation ...
US-1,028,0213 Broadly cross-reactive HIV-1 Env-specific antibodies
Provided herein are HIV-1-specific transforming antibodies (tAbs) and antigens that are recognized by HIV-1-specific tAbs. Also provided herein are methods for...
US-1,028,0212 Composite comprising antibody capable of binding to intranuclear protein of influenza virus
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
US-1,028,0211 Engineered rabbit antibody variable domains and uses thereof
The present invention relates to methods for screening and producing polypeptides that immunospecifically bind to an antigen, which: polypeptides comprise...
US-1,028,0210 Peptide compounds for suppressing inflammation
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The...
US-1,028,0209 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28
The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising...
US-1,028,0208 TMIGD2 and its derivatives as blockers or binders of cancer-expressed HHLA2 for immunotherapies
Provided are methods of treating an HHLA2-bearing tumor in a subject with a fusion protein comprising an IgV-like domain of a TMIGD2 sufficient to treat the...
US-1,028,0207 FcRn-specific human antibody and composition for treatment of autoimmune diseases
The present invention relates to a human antibody specific for FcRn that is a receptor with a high affinity for IgG, a production method thereof, a composition...
US-1,028,0206 Methods for protein and peptide reduction
Methods and systems are provided herein for on-line preparation of a sample for mass spectrometry. In accordance with various aspects of applicant's teachings,...
US-1,028,0205 Method for treating cancer with an activated T lymphocyte that selectively recognizes a cancer cell consisting...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,028,0204 Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same
A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and...
US-1,028,0203 Compositions and related methods for modulating alkaloid production by controlling PMT promoter activation...
Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by...
US-1,028,0202 Peptide
This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6),...
US-1,028,0201 Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
US-1,028,0200 Non-natural consensus albumin binding domains
Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in...
US-1,028,0199 Coronavirus proteins and antigens
Disclosed herein are embodiments of a method for collecting, extracting or eluting proteins and antigens from cells infected with coronavirus. The coronavirus...
US-1,028,0198 Therapeutic agents for reducing parathyroid hormone levels
Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of...
US-1,028,0197 Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands
A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates...
US-1,028,0196 Heparin affinity tag and application thereof
In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of...
US-1,028,0195 Virus reduction method
Methods are provided for enhancing reduction of virus and viral DNA levels in protein preparations.
US-1,028,0194 Short chain PEGylation of amino acid monomers glutamine, lysine and peptides formed thereby
Novel synthesized amino acids of glutamine and lysine that are directly PEGylated with small, monodisperse PEGs, and a novel process for creating novel amino...
US-1,028,0193 Isoxazolidine derivatives
Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for...
US-1,028,0192 Methods for the synthesis of functionalized nucleic acids
The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising ...
US-1,028,0191 Non-enzymatic, salt-mediated synthesis of polynucleic acids
Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid...
US-1,028,0190 Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof...
Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including ...
US-1,028,0189 Method for the synthesis of aminoalkylenephosphonic acid
A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an...
US-1,028,0188 Fluorine-containing bisphosphonic acid derivative and use thereof
A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an...
US-1,028,0187 Mononucleotide-dithiocarbamate complex
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
US-1,028,0186 Silane guanidinate derivatives useful for low temperature deposition of silicon-containing materials
A guanidinate silane compound of any of formulae (I)-(IV) is described, having utility as a precursor in vapor deposition processes for forming a ...
US-1,028,0185 Mononuclear salen indium catalysts and methods of manufacture and use thereof
The present application provides salen indium catalysts of the following general structure wherein R is a coordinating alkoxide comprising at least one...
US-1,028,0184 Heterocyclic kinase inhibitors
The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof...
US-1,028,0183 Therapeutic agent for treating tumors
The present disclosure relates to a therapeutic agent of the formula: Z--C(.dbd.O)--(CH.sub.2)n-.PHI.-S--S--(CRR')m-(CH.sub.2)p-C(.dbd.O)--NH--- ...
US-1,028,0182 Histone deacetylase inhibitors
This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
US-1,028,0181 Coloring composition, anisotropic light absorption film, laminate, polarizing plate, image display device and...
A coloring composition containing one or more species of compounds represented by Formula (I) or Formula (II) below, wherein each of R.sub.1 and R.sub.2...
US-1,028,0180 Macrocyclic purines for the treatment of viral infections
This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
US-1,028,0179 Spiroquinoxaline derivatives as inhibitors of non-apoptotic regulated cell-death
The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such...
US-1,028,0178 Compound for inhibiting binding between DX2 protein and p14/ARF protein, and pharmaceutical composition for...
Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an...
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