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Patent # Description
US-1,028,7635 Micro-RNA based diagnoses of ovarian and other cancers via sub-terahertz vibrational spectroscopy
Certain exemplary embodiments can provide a method, which comprises causing a determination to be made that a body fluid sample is from a patient with cancer....
US-1,028,7634 RNA-biomarkers for diagnosing prostate cancer
The invention relates to the identification and selection of differentially expressed transcripts (biomarker) in tumor cells. Specific determination of the...
US-1,028,7633 TYRP1, a natural miRNA sponge, and its use in managing human melanoma aggressiveness
The present invention relates to methods and reagents for the treatment of melanoma and/or of metastatic melanoma that directly or indirectly target TYRP1 RNA...
US-1,028,7632 Methods for profiling and quantitating cell-free RNA
The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to...
US-1,028,7631 Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate...
US-1,028,7630 Single cell nucleic acid detection and analysis
Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
US-1,028,7629 Methods and compositions for nucleic acid sequencing
The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for...
US-1,028,7628 Methods and kits for identifying polypeptide binding sites in a genome
The present invention provides, inter alia, methods and kits for identifying where a polypeptide of interest binds in a genome. The methods include a) carrying...
US-1,028,7627 Multiplexed linking PCR
The invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides, as...
US-1,028,7626 Recognition sequences for I-CreI-derived meganucleases and uses thereof
Methods of cleaving double-stranded DNA that can be recognized and cleaved by a rationally-designed, I-CreI-derived meganuclease are provided. Also provided are...
US-1,028,7625 Methods and kits for separating nucleic acids by size
Disclosed are methods and kits for isolating nucleic acids having a size above a desired cut-off size from a nucleic acid containing sample. The method...
US-1,028,7624 Reagents and methods for the analysis of linked nucleic acids
Reagents and methods for the analysis of nucleic acids (e.g. genomic DNA) of circulating microparticles (i.e. microparticles originating from blood) are...
US-1,028,7623 Methods and compositions for targeted nucleic acid sequencing
The present invention is directed to methods, compositions and systems for capturing and analyzing sequence information contained in targeted regions of a...
US-1,028,7622 Plurality of transposase adapters for DNA manipulations
The present invention relates to transposase adapters and uses thereof, including uses in preparing DNA molecules, in vitro amplification, sequencing of nucleic...
US-1,028,7621 Targeted chromosome conformation capture
The invention relates to a method which enables the possibility to capture chromosome conformation as well as a kit containing components useful to be used the...
US-1,028,7620 Digital polymerase fidelity assay
Methods of determining polymerase fidelity are provided. In one embodiment, the method comprises filling a gapped plasmid with a polymerase to form a gap-filled...
US-1,028,7619 Measurement method for dehydrogenase and substrate concentration thereof, electron mediator, and measurement...
A method for measuring concentration of dehydrogenase and substrate thereof in the presence of living cells, wherein an electron mediator that is hard to be...
US-1,028,7618 Wash monitor composition, device, and method of use
A composition for monitoring the efficacy of a decontamination process is provided, the composition comprising a cellulose polymer and a predetermined quantity...
US-1,028,7617 Methods for in vitro--in vivo efficacy determination
The invention provides methods for determining and evaluating the in vitro-in vivo activity relationship of the efficacy of families of compounds for infectious...
US-1,028,7616 Label free biosensors, gram-negative bacteria detection, and real-time and end point determination of...
Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample...
US-1,028,7615 Sophorolactone production
The present invention relates to a process for selectively producing sophorolactone without use of organic solvent, comprising the steps of: --pre-cultivating...
US-1,028,7614 Production of nucleic acid
A method for the production of nucleic acid encoding a target protein. The method comprises (a) providing an array of RNA or DNA molecules including one or more...
US-1,028,7613 Structuring fats and methods of producing structuring fats
Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific...
US-1,028,7612 Modified cyanobacteria
Provided is a cyanobacterium improved in fatty acid productivity. A method for producing a modified cyanobacterium, comprising causing loss of function of a...
US-1,028,7611 Engineering the pathway for succinate production
This invention relates to biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The...
US-1,028,7610 Integrated process for coproducing alcohol and organic acid from lignocellulosic material
The invention relates to an integrated process for alcohol production and organic acid production from lignocellulosic material.
US-1,028,7609 Plant activator composition
A plant activator composition increases the concentration of terpenes a terpinoids in aromatic plant oils, and hence resulting in an increased concentration of...
US-1,028,7608 Tissue selective transgene expression
Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise...
US-1,028,7607 Tissue selective transgene expression
Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise...
US-1,028,7606 Genomic engineering of pluripotent cells
Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites....
US-1,028,7605 Lepidopteran-active Cry1Da1 amino acid sequence variant proteins
Engineered Cry1Da amino acid sequences are provided that exhibit improved Lepidopteran insecticidal activity and an enhanced Lepidopteran spectrum compared to...
US-1,028,7604 Gene for increasing the production of plant biomass and/or seeds and method for use thereof
A technique by which the production of plant biomass can be significantly increased is provided. A protein phosphatase 2C gene having 3 consensus sequences...
US-1,028,7603 Brassica plants comprising mutant DA1 alleles
The present invention relates to methods and means to increase seed weight in Brassica. More specifically, the invention relates to mutant DA1 genes in Brassica...
US-1,028,7602 RNA virus-derived plant expression system
A process of expressing a sequence of interest in a plant, plant part, or plant cell culture, comprising: (a) providing a plant, plant part, or plant cell...
US-1,028,7601 Indole-derived compound production
Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a...
US-1,028,7600 Compositions and methods for differential regulation of fatty acid unsaturation in membrane lipids and seed oil
Aspects of the invention provide methods for differential regulation of fatty acid unsaturation in seed oil and membrane lipids of plants based on modulation of...
US-1,028,7599 Isopropylmalate synthase from Nicotiana tabacum and methods and uses thereof
The present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting...
US-1,028,7598 Methods for preparing pecific polypeptide-binding antibodies
Various embodiments are directed to transgenic plants, including transgenic tobacco plants and derivative seeds, genetically modified to impede the transport of...
US-1,028,7597 Wound inducible expression construct and a method of its preparation
The present invention provides a wound inducible expression construct and a method of its preparation. The invention provides a methods for isolation of an...
US-1,028,7596 Regulating alkaloids
MPO1 and MPO2 can be regulated for either decreasing or increasing alkaloid levels in plants, in particular in Nicotiana plants. In particular, suppressing or...
US-1,028,7595 Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene...
US-1,028,7594 Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated...
The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the...
US-1,028,7593 Filamentous fungus mutant strain and use thereof
A filamentous fungus mutant strain in which enzyme production inhibition caused by glucose is suppressed is constructed, and a method of producing a...
US-1,028,7592 Bacillus host
The invention provides Bacillus host cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid...
US-1,028,7591 Enhanced protein expression
The present invention relates in general to bacterial cells having a genetic alteration that results in increased expression of a protein of interest and...
US-1,028,7590 Methods for generating libraries with co-varying regions of polynuleotides for genome modification
The invention provides methods for introducing co-varying paired nucleic acids into a vector such under separate transcriptional control. An oligonucleotide is...
US-1,028,7589 Targeting microRNAs for metabolic disorders
Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of...
US-1,028,7588 Compositions and methods to treating hemoglobinopathies
Embodiment herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat ...
US-1,028,7587 Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those...
The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with,...
US-1,028,7585 Therapy
IRF-7 inhibitors have been found to be useful in the treatment of infections, such as bacterial infections. Suitable inhibitors include siRNA molecules as well...
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