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Patent # Description
US-1,028,7584 Compounds and methods for the modulation of COMP
In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell. In certain embodiments,...
US-1,028,7583 Oligonucleotide decoys for the treatment of pain
Provided are therapeutic agents such as double-stranded nucleic acids, termed oligonucleotide decoys, pharmaceutical compositions comprising the same, and...
US-1,028,7582 Organic compositions to treat HSF1-related diseases
The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically...
US-1,028,7581 Cell penetrating peptides for intracellular delivery of molecules
The present invention relates to a new family of cell-penetrating peptides, comprising an amino acid sequence ...
US-1,028,7580 Molecular re-engineering of excitation-inhibition balance in memory circuits
Disclosed are memory-regulating agents and methods that target actin binding LIM protein family, member 3 (ABLIM3). Specifically, the disclosure provides...
US-1,028,7579 Gene vector
A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a...
US-1,028,7578 DNAzyme-nanoparticle conjugates and methods of use thereof
The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to...
US-1,028,7577 Nucleic acid arrays of spatially discrete features on a surface
The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface....
US-1,028,7576 Enzymatic encoding methods for efficient synthesis of large libraries
Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent...
US-1,028,7575 Methods for generating barcoded combinatorial libraries
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive...
US-1,028,7574 Oligonucleotide replacement for di-tagged and directional libraries
Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5' and 3' tags, and to make directional libraries that are...
US-1,028,7573 Combinatorial DNA taggants and methods of preparation and use thereof
DNA taggants in which the nucleotide sequences are defined according to combinatorial mathematical principles. Methods of defining nucleotide sequences of the...
US-1,028,7572 Protein scaffolds and methods of use
This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this...
US-1,028,7571 Genetically modified microorganism for improved production of fine chemicals on sucrose
The present invention relates to a modified microorganism having, compared to its wildtype, --a reduced activity of an enzyme encoded by the ptsA-gene, --a...
US-1,028,7570 System and method for collecting a sample of nucleic acid
A system for collecting biomolecules comprising an extractor assembly comprising a top cap, an extractor core, an extractor core adaptor, an extractor body...
US-1,028,7569 Enzyme for biosynthesis of isoprene and isopentenyl, and mutant thereof
The invention provides a polypeptide capable of using 4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) as a substrate to produce isoprene, a nucleic acid...
US-1,028,7568 Methods for extracting and purifying non-denatured proteins
Materials and methods for extracting and purifying proteins are provided. For example, the materials and methods provided herein can be used for extracting and...
US-1,028,7567 Polynucleotides encoding engineered tyrosine ammonia lyase variants
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL...
US-1,028,7566 DHAD variants and methods of screening
Methods of screening for dihydroxy-acid dehydratase (DHAD) variants that display increased DHAD activity are disclosed, along with DHAD variants identified by...
US-1,028,7565 Isoprene synthase and method of preparing isoprene using thereof
Provided are a novel isoprene synthase derived from sweet potato and a method of preparing isoprene using the same, and more specifically, a novel isoprene...
US-1,028,7564 Procoagulant compounds
The present disclosure provides protease-activatable procoagulant compounds comprising a procoagulant polypeptide, e.g., a procoagulant peptide and/or clotting...
US-1,028,7563 Process for degrading mannan-containing cellulosic materials
The present invention relates to processes comprising enzymatic degradation of mannan-containing cellulosic materials for producing a hydrolyzate. The invention...
US-1,028,7562 Alicyclobacillus variants and polynucleotides encoding same
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
US-1,028,7561 Polypeptide having a polyester degrading activity and uses thereof
The present invention relates to a new isolated polypeptide comprising an amino acid sequence having at least 94%, 95%, 99% or 100% identity to the full length...
US-1,028,7560 Recombinase mutants
Presented herein are recombinases for improved recombinase-mediated amplification of nucleic acids, such as a PCR-library having single-stranded adapter...
US-1,028,7559 Hyperactive PiggyBac transposases
The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same,...
US-1,028,7558 Microorganisms for succinic acid production
The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene....
US-1,028,7557 Yeast strains producing mammalian-like complex N-glycans
Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or...
US-1,028,7556 Luciferase showing orange luminescence
A luciferase that includes an amino acid sequence in which a mutation is introduced into an amino acid sequence of a luciferase derived from Luciora kuroiwae....
US-1,028,7555 Rotavirus-like particle production in plants
A method of producing a rotavirus-like particle (RLP) in a plant is provided. The method comprises expressing within a host or host cell for example a plant,...
US-1,028,7554 Induced pluripotent stem cell model for Fabry disease and use thereof
The present invention relates to an induced pluripotent stem cell model of Fabry disease, a preparation method thereof, and a use of the same for the study of...
US-1,028,7553 In vitro method for culturing stem cells
There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule...
US-1,028,7552 Generation of hepatocytes from pluripotent stem cells
Methods are provided for producing differentiated cells from stem cells, including producing hepatocytes. Compositions thereof are also provided, as are methods...
US-1,028,7551 Medium composition for culturing stem cells
The present disclosure relates to a medium composition for culturing stem cells, and more specifically, to a medium composition for culturing mesenchymal stem...
US-1,028,7550 Serum-free chemically defined cell culture medium
Embodiments of chemically defined cell culture media containing nutrients and growth factors free of any serum for culturing cells such as mesenchymal stem...
US-1,028,7549 Muscle stem cell in vitro culture method and application
Provided is a muscle stem cell in vitro culture method. A muscle stem cell is cultivated in vitro by using a cell culture medium of a cell factor added with a...
US-1,028,7548 Method and device for closed system culture of cartilage tissue
The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform....
US-1,028,7547 Enrichment and characterization of human corneal endothelial cells (hCENC) with novel monoclonal antibody
This invention refers to an antibody or an antigen binding portion thereof, that binds specifically to human corneal endothelial cells (hCENCs), wherein the...
US-1,028,7546 Kits for neural conversion of human embryonic stem cells
The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent...
US-1,028,7545 Streptomyces and method for producing milbemycin A3 using same
Provided are a Streptomyces (Streptomyces hygroscopicus) HS7523 and a method for preparing milbemycin A3 by culturing the Streptomyces. The Streptomyces...
US-1,028,7544 Bacterial fermentation methods and compositions
The present invention provides methods for the cultivation of the Methylobacterium genus of bacteria. In particular the method provides methods for the...
US-1,028,7543 Process and device for isolating cells from biological tissue
The invention is directed to a Perfusion device for biological tissues comprising a casing having two parts, a first part (1) and a second part (9), a holder...
US-1,028,7542 Apparatus for automatically preparing cell-free proteins and method for preparing proteins using same
An automated cell-free protein production system comprises: a protein expression reaction unit comprising a reaction vessel that includes a plurality of...
US-1,028,7541 Cell culture vessel coated with laminin fragment in dry state
Provided is a cell culture vessel characterized in that a surface to be in contact with cells is coated with a laminin fragment having integrin .alpha.6.beta.1...
US-1,028,7540 Construction method of a fermenter for a biogas plant
A construction method of a fermenter, which has a fermenter cage and a fermenter shell made of metal, for use in a biogas plant, wherein the fermenter shell...
US-1,028,7539 Rotating culture vessel and automatic cell culture apparatus using same
Disclosed is a rotating culture vessel based on a rotating culture technology using an RWV, by which cell seeding, liquid medium exchange, quality control and...
US-1,028,7538 Device for producing a photosynthetic culture by means of a photo-bioreactor and at least one light distributor
Disclosed is a photosynthetic culture production device including at least one photo-bioreactor chamber having a supply/discharge unit, and including: an...
US-1,028,7537 Clarification method
In a clarification method for a beverage liquid, in particular for producing beer, the beverage liquid, after it passes through a fermentation stage, is...
US-1,028,7536 Small scale grain malting apparatus and method
An apparatus and method for malting grain having a hollow cylindroconical vessel and a first, smaller removable false bottom retaining grain used in cleaning,...
US-1,028,7535 Solid block comprising one or more domains of prismatic or cylindrical shape and production thereof
The present invention relates to a solid block comprising a solidified material, characterized in that the solid block comprises one or more domains of...
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