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Patent # Description
US-1,028,7332 Self-assembled beta solenoid protein scaffolds
The present invention provides amyloid fibrils comprising a plurality of modified .beta. solenoid protein (mBSP) monomers. The mBSP monomers are modified to...
US-1,028,7331 Mitochondrial proteins constructs and uses thereof
Disclosed are fusion protein constructs comprising a functional mitochondrial protein, that can enter mitochondria within intact cells. Further disclosed are...
US-1,028,7330 Methods and compositions relating to CRM197
The present invention provides novel methods of producing diphtheria toxin. In particular, the present invention provides novel methods of producing nontoxic...
US-1,028,7329 Insecticidal polypeptides having broad spectrum activity and uses thereof
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having...
US-1,028,7328 Treatment of diabetes, toll-like receptor 4 modulators and methods for using the same
The present invention relates to treatment of diabetes, toll-like receptor 4 (TLR-4) modulators and methods for using the same. Particularly, the present...
US-1,028,7327 Protein A mutants having high alkali resistance and methods of use thereof
A series of protein A mutants having high alkali resistance, and methods of using the protein A mutants are provided. The protein A mutants have a high binding...
US-1,028,7326 Anti-inflammatory properties of a surface protein of propionibacterium freudenreichii
Disclosed is a polypeptide including or consisting of the amino acid sequence SEQ id n.sup.o:1, for use in the treatment or prevention of an inflammatory...
US-1,028,7325 Antibody capable of binding to intranuclear protein of influenza virus, composite, detection device and method...
The present invention is an antibody including an amino acid sequence, wherein the amino acid sequence includes, in an N- to C-direction, the following...
US-1,028,7324 Norovirus derived immunogenic compositions and methods
The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a...
US-1,028,7323 Therapeutic HPV18 vaccines
Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
US-1,028,7322 Complexes of cytomegalovirus proteins
An isolated human cytomegalovirus (HCMV) membrane protein complex that comprises gH, gL and at least one more HCMV glycoprotein is provided. In some embodiments...
US-1,028,7321 Re-directed immunotherapy
The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting...
US-1,028,7320 Anti-lymphoma peptides
The present invention provides a peptide which: (i) consists of 10 to 16 amino acids; (ii) has at least 8 cationic amino acids with either (a) a side chain...
US-1,028,7319 Biologically active peptides
A peptide or peptide derivative comprising: (i) WDLYFEIVW (SEQ ID NO: 1); or (ii) a variant amino acid sequence comprising one, two, three or four L-amino acid...
US-1,028,7318 Viral vector for the targeted transfer of genes in the brain and spinal cord
The invention relates to novel peptides, polypeptides or proteins which bind specifically to brain cells and/or to the spinal cord. The peptides, polypeptides,...
US-1,028,7317 Proprotein convertase subtilisin kexin type 9 (PCSK9) allosteric binding ligands to modulate serum low density...
This invention is related to the field of hypercholesterolemia. In particular, the invention provides compositions and methods to modulate circulating levels of...
US-1,028,7316 Process for preparation of nitrogen mustard derivatives
The present invention provides a process for the production of compound (III) or a deprotected product thereof: comprising reacting compound (II) with...
US-1,028,7315 Method for purifying immunoglobulin
The present invention relates to a method for purifying an immunoglobulin, and more particularly, to a method for purifying an immunoglobulin, which comprises:...
US-1,028,7314 Methods of reducing level of one or more impurities in a sample during protein purification
The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in...
US-1,028,7313 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays
The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2' and/or the 5'-hydroxy functionalities of the ribose...
US-1,028,7312 Cyclic peroxides as prodrugs for selective delivery of agents
Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a...
US-1,028,7311 Modified fluorinated nucleoside analogues
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever...
US-1,028,7310 Process for the preparation of diosmin
The present invention relates to a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine...
US-1,028,7309 Disaccharide intermediate and synthesis method thereof
The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically...
US-1,028,7308 Compounds, compositions, and methods for the treatment of cancers
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
US-1,028,7307 Crystalline forms of tenofovir alafenamide
The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the...
US-1,028,7305 Substituted piperidine compound and use thereof
Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): ##STR00001## ...
US-1,028,7304 Acid, solvent, and thermal resistant metal-organic frameworks
The disclosure provides for thermal, solvent, and/or acid resistant metal organic frameworks and the use of these frameworks in devices and methods for gas...
US-1,028,7303 Compositions and methods for inhibiting arginase activity
The disclosure relates to a novel class of compounds that exhibit activity inhibitory activity toward arginase, and pharmaceutical compositions comprising the...
US-1,028,7302 Method for synthesis of lithium fluorinated borate salts
An effective method to synthesize Li borate salt such as Li(RfO).sub.aBF.sub.b, in which a and b are integers, and a+b=4, has been disclosed. Using RfO-TMS as...
US-1,028,7301 Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,028,7300 Heterocyclic derivatives as modulators of kinase activity
The invention provides novel imidazol-piperidinyl derivatives of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, W, X.sup.1, X.sup.2, X.sup.3, X.sup.4...
US-1,028,7299 Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity
A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogs thereof, being potent modulators of human TNFa activity, are accordingly...
US-1,028,7298 Nitrogen-containing analogs of salinomycin, synthesis and use against cancer stem cells and malaria
The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formula...
US-1,028,7297 Epoxyazulene derivatives useful for treating cancer and diabetes
Disclosed is a compound of formula (I) in which R.sup.1-R.sup.5 and X.sup.1 are as described herein. Also provided are methods of using a compound of formula...
US-1,028,7296 Process for the preparation of (S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4- ...
An invention includes a process for the preparation of (S)-2((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a- ...
US-1,028,7295 TGF-.beta. inhibitors
Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the...
US-1,028,7294 Compounds for use in treating or preventing cancerous diseases
The invention relates to new compounds of formula (I) that are useful in medicine, specifically in treating or preventing cancerous diseases in a mammal, to...
US-1,028,7293 Bicyclic heterocyclic compounds as PDE2 inhibitors
The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of...
US-1,028,7292 CXCR7 antagonists
Compounds having formula I, ##STR00001## or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7,...
US-1,028,7291 Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
seco-Cyclopropapyrroloindole compounds of formula (I) ##STR00001## where Hal, R.sup.1, R.sup.2, and R.sup.3 are as defined in the application, are potent...
US-1,028,7290 Compositions useful in treating brain-related diseases or disorders and methods using same
The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method...
US-1,028,7289 Process for preparing beta 3 agonists and intermediates
The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of...
US-1,028,7288 Factor XIa macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
US-1,028,7287 Process development of a pyridine-containing NK-1 receptor antagonist
The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those...
US-1,028,7285 4H-pyrido[1,2-A]pyrimidin-4-one compounds
The present invention relates to compounds of the formula I or II: (I) (II) processes for their preparation and their use as pharmaceutical agents or...
US-1,028,7284 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and...
US-1,028,7283 Read-through compound prodrugs suppressing premature nonsense mutations
Premature termination codon readthrough prodrug compounds, compositions thereof, and methods of making and using the same are provided. In certain embodiments,...
US-1,028,7282 Methods and agents for treating disease
The present invention provides compounds having the general structural formula (I) [formula should be inserted here] and pharmaceutically acceptable derivatives...
US-1,028,7281 Pyrazoline derivatives as insecticidal compounds
The present invention relates to compounds of formula I ##STR00001## wherein P is selected from P1 and P2, or P and R.sup.5 together are P3 ##STR00002## ...
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