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|United States Patent||RE43,279|
|Benner , et al.||March 27, 2012|
The invention includes a method of reducing urea concentration in a subject's serum. Such a method comprises administering to the subject (e.g., a mammal such as a human) a composition comprising an oligopeptide (or oligopeptides) having activity in reducing urea concentration in the subject's serum as determined by a mouse renal reperfusion test, wherein the oligopeptide comprises the sequence AQG or MTRV (SEQ ID NO:1), AQGV (SEQ ID NO:2) or LAGV (SEQ ID NO:4).
|Inventors:||Benner; Robbert (Barendrecht, NL), Khan; Nisar Ahmed (Rotterdam, NL)|
|Filed:||March 17, 2011|
|Application Number||Filing Date||Patent Number||Issue Date|
|Reissue of:||11346450||Feb., 2006||7576174||Aug., 2009|
|Mar 29, 2000 [EP]||00201139|
|Current U.S. Class:||530/300 ; 530/330|
|Current International Class:||C07K 2/00 (20060101)|
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|6844315||January 2005||Khan et al.|
|6921751||July 2005||Khan et al.|
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|7358330||April 2008||Khan et al.|
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|7662776||February 2010||Khan et al.|
|7786084||August 2010||Benner et al.|
|7795226||September 2010||Benner et al.|
|2002/0064501||May 2002||Khan et al.|
|2002/0147306||October 2002||Lin et al.|
|2003/0049273||March 2003||Gallo et al.|
|2003/0113733||June 2003||Khan et al.|
|2003/0119720||June 2003||Khan et al.|
|2003/0166556||September 2003||Khan et al.|
|2003/0186244||October 2003||Margus et al.|
|2003/0212253||November 2003||Hammond et al.|
|2003/0215434||November 2003||Khan et al.|
|2003/0219425||November 2003||Khan et al.|
|2003/0220257||November 2003||Benner et al.|
|2003/0220258||November 2003||Benner et al.|
|2003/0220259||November 2003||Benner et al.|
|2003/0220260||November 2003||Khan et al.|
|2003/0220261||November 2003||Khan et al.|
|2003/0224995||December 2003||Khan et al.|
|2004/0013661||January 2004||Wensvoort et al.|
|2004/0208885||October 2004||Khan et al.|
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|2005/0107314||May 2005||Gorczynski et al.|
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|2006/0173162||August 2006||Djurup et al.|
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|WO 03/029292||Apr., 2003||WO|
|WO 2004/093897||Nov., 2004||WO|
|WO 2005/097163||Oct., 2005||WO|
|WO 2006/069198||Jun., 2006||WO|
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